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:: Volume 20, Issue 3 (10-2018) ::
J Gorgan Univ Med Sci 2018, 20(3): 24-30 Back to browse issues page
Effect of hydroalcoholic extract of Ferula persica resin on induced rheumatoid arthritis by Freund's complete adjuvant in rat
Nahid Rabani1 , Maryam Tehranipour * 2, Naser Mahdavi Shahri3
1- M.Sc in Animal Physiology, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
2- Associate Professor, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. maryam_tehranipour@mshdiau.ac.ir , maryam_tehranipour@mshdiau.ac.ir
3- Professor, Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract:   (10251 Views)
Background and Objective: Rheumatoid arthritis is an autoimmune-inflammatory disease with possible joint destruction and disability. Persica plant, seems contain anti-inflammatory capabilities. This study was done to determine the effect of hydroalcoholic extract of Ferula persica resin on induced rheumatoid arthritis by Freund's complete adjuvant in rat.
Methods: In this experimental study, 36 male Wistar rats (200-250 g) and 8 weeks old were randomly allocated in 6 groups including normal group, positive control, negative control, and groups treated with the hydroalcoholic extract of persica resin with 25, 50 and 75 mg/kg/bw doses. The resin of persica was extracted by Maceration method. On the first day, inflammation was induced with injection of 0.2 ml of Freund's complete adjuvant into the right knee joint of rats and from the fifteenth day hydroalcoholic extract was injected intraperitoneally and daily for 15 days. On the 30th day, blood samples were taken from hearts for rheumatoid factor measurement. Histological slides were prepared from knee joint.
Results: The level of RF in the three treatment groups was significantly reduced compared to the negative control group (p<0.05). Destruction of cartilage were observed in treated group with dose of 25 mg/kg/bw in comparision with positive control group, treated group with 50 and 75 mg/kg/bw doses. Also in the negative control group, synovial hyperplasia, pannus and the destruction of cartilage were observed.
Conclusion: It seems that hydroalcoholic extract of Ferula persica resin can causes dose dependent reduction of inflammation and destruction of cartilage result from induced rheumatoid arthritis in the rats.
Keywords: Rheumatoid arthritis, Ferula persica resin, Inflammation, Knee joint
Full-Text [PDF 412 kb] [English Abstract]   (16068 Downloads) |   |   Abstract (HTML)  (360 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
* Corresponding Author Address: Associate Professor, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. maryam_tehranipour@mshdiau.ac.ir
References
1. Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev. 2007 Nov; 7(1): 59-64. doi:10.1016/j.autrev.2007.07.001
2. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004 Dec; 80(6 Suppl):1678S-88S. doi:10.1093/ajcn/80.6.1678S
3. Ahmadi M, Rasekh H, Kamali Nejad M, Zare A. Anti-inflammatory effects of total extract of Curcuma amada Roxb. in a rheumatoid arthritis rat model. J Med Plants. 2008; 7(1): 21-28. [Article in Persian]
4. Aghaei M, Sedighi S, Behnam pour N, Hezar Khani S, Hashemizadeh P, Shirashiani M, et al. [The study of bone mineral density in postmenopausal women with rheumatoid arthritis]. J Shahrekord Univ Med Sci. 2013; 15(2): 53-60. [Article in Persian]
5. Molenaar E, Voskuyl A, van der Horst-Bruinsma IE, Schreuder GM, Zanelli E, Dijkmans B. Influence of HLA polymorphism on persistent remission in rheumatoid arthritis. Ann Rheum Dis. 2002 Apr; 61(4): 351-53. doi:10.1136/ard.61.4.351
6. Smolen JS, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003 Jun; 2(6): 473-88. doi:10.1038/nrd1109
7. Paleolog EM. Angiogenesis in rheumatoid arthritis. Arthritis Res. 2002; 4 Suppl 3: S81-90. doi:10.1186/ar575
8. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010 Sep; 69(9): 1580-88. doi:10.1136/ard.2010.138461
9. Ramadan G, El-Beih NM, Talaat RM, Abd El-Ghffar EA. Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis. Int J Rheum Dis. 2017 Feb; 20(2): 203-13. doi:10.1111/1756-185X.12666
10. Zamani Gandomani M, Foruzandeh Molaali A, Zamani Gandomani Z, Madani H, Moshtaghian SJ. [Evaluation of anti-inflammatory effect of hydroalcoholic extract of Mangrove (Avicennia Marina) leaves in male rats]. Med J Tabriz Univ Med Sci. 2012. 34(4): 80-85. [Article in Persian]
11. Zargari A. [Medicinal plants]. 4th ed. Tehran: Tehran University Publications. 1988; pp: 592-602. [Persian]
12. Afifi FU, Abu-Irmaileh B. Herbal medicine in Jordan with special emphasis on less commonly used medicinal herbs. J Ethnopharmacol. 2000 Sep; 72(1-2): 101-10.
13. Shahverdi AR, Saadat F, Khorramizadeh MR, Iranshahi M, Khoshayand MR. Two matrix metalloproteinases inhibitors from Ferula persica var. persica. Phytomedicine. 2006 Nov; 13(9-10): 712-17. doi:10.1016/j.phymed.2006.01.003
14. Parvardeh S, Niapoor M, Nassiri Asl M, Hosseinzadeh H. [Antinociceptive, anti-inflammatory and acute toxicity effects of Pistacia vera L. gum extract in mice and rat]. J Med Plants. 2002; 4(4): 58-67. [Artricle in Persian]
15. Pouraboli I, Hajizadeh S, Najafipour H, Khoshbaten A, Rasaei MJ. [Does PGE2 mediate indomethacin and theophylline effects on joint diameter and vascular response to saphenous nerve stimulationin chronically inflamed rat knee joint?] Physiology and Pharmacology. 2008; 12: 68-75. [Article in Persian]
16. Sattar Z, Iranshahi M. Phytochemistry and pharmacology of Ferula persica Boiss.: A review. Iran J Basic Med Sci. 2017 Jan; 20(1): 1-8. doi:10.22038/ijbms.2017.8085
17. van Schaardenburg D, Lagaay AM, Otten HG, Breedveld FC. The relation between class-specific serum rheumatoid factors and age in the general population. Br J Rheumatol. 1993 Jul; 32(7): 546-49.
18. Williams RC Jr. Rheumatoid factors: Historical, prospective, origin and possible role in disease. J Rheumatol. 1992; 32: 42-45.
19. Ghadiri T, Najafipour H, Shakib MR. [The effect of intra-articular injection of ywo anti TNF drugs on histopathology and effect of local Infusion of these drugs on blood flow of chronically inflamed joints in rabbit]. J Kerman Univ Med Sci. 2010; 16(1): 1-14. [Article in Persian]
20. Ashrafihelan J, Roohollah F, Rafiei Tehrani S. [Pathological study of arthritis induced by type 2 bovine collagen and Freund’s complete adjuvant in rat]. Journal of Veterinary Research. 2011; 66(1): 65-71. [Article in Persian]
21. Li QH, Xie WX, Li XP, Huang KT, Du ZH, Cong WJ, et al. Adenosine A2A receptors mediate anti-inflammatory effects of electroacupuncture on synovitis in mice with collagen-induced arthritis. J Evid Based Complementary Altern Med. 2015; Article ID 809560.
22. Ma JD, Zhou JJ, Zheng DH, Chen LF, Mo YQ, Wei XN, et al. Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis. Mediators Inflamm. 2014; 2014: 179284. doi:10.1155/2014/179284
23. Iranshahi M, Askari M, Sahebkar A, Adjipavlou- Litina D. Evaluation of antioxidant, anti-inflammatory and lipoxygenase inhibitory activities of the prenylated coumarin umbelliprenin. DURU. 2009; 17(2): 99-103.
24. Rafiei H, Khayatzadeh J. [Cartilage glycosaminoglycans in wound healing of the pinna in rabbits by Medicago Sativa extract]. J Zanjan Univ Med Sci. 2012; 20(5): 1-11. [Article in Persian]
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Rabani N, Tehranipour M, Mahdavi Shahri N. Effect of hydroalcoholic extract of Ferula persica resin on induced rheumatoid arthritis by Freund's complete adjuvant in rat. J Gorgan Univ Med Sci 2018; 20 (3) :24-30
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Volume 20, Issue 3 (10-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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