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Prevalence of suspected Gilbert’s syndrome in Golestan province, northern Iran (2014)
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Azadeh Aliarab1    , Bahram Yaghmaei2 , Sayyed Mohammad Hossein Ghaderian3 , Mergen Kalavi4 , Masoud Khoshnia5 , Gholamreza Roshandel6 , Zahra Hesari7 , Hamid Reza Joshagani * 8 |
1- Ph.D Candidate in Clinical Biochemistry, Department of Biochemistry, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
2- Professor of Clinical Biochemistry, Department of Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Associate Professor of Medical Genetics, Department of Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- General Physician, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
5- Gastroenterologist and Hepatologist, Gorgan, Iran.
6- Research Associate Professor of Epidemiology (By Research), Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran.
7- Assitant Professor of Clinical Biochemistry, Department of Laboratory Science, School of Allied Medical Sciences, Golestan University of Medical Sciences, Gorgan, Iran.
8- Professor of Clinical Biochemistry, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. , joshaghani@goums.ac.ir |
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Abstract: (5875 Views) |
Background and Objective: Gilbert's syndrome is a relatively common genetic disorder, which is caused by defection in uridine diphosphate glucuronosyl transferase enzyme. The indirect bilirubin increases in this syndrome, although the function of the liver is normal. Gilbert's syndrome can be seen in 3 to 10% of different populations. According to the differences in ethnic groups in Golestan Province, no studies have been conducted on the prevalence of the syndrome in the province, so far.This study was conducted to determine the prevalence of suspected Gilbertʼs syndrome in Golestan province in north of Iran.
Methods: This descriptive-analytical study was performed on 1664 subjects with 18-45 years old referring to rural and urban health centers in Golestan province, North of Iran during 2014. Liver function tests were normal in subjects. Fasting blood samples were taken from each subject and total bilirubin was tested. People with a total bilirubin of more than 1.5 mg/dl were treated with a single oral dose of rifampin 600 mg. After taking rifampicin, the individuals with an indirect bilirubin level of more than 1.3 mg/dl were found suspected of Gilbert’s syndrome.
Results: The prevalence of suspected Gilbert's syndrome was 5.8%. Moreover, suspected Gilbert’s syndrome was more common in males than females (10% in males and 4.3% in females) (P<0.05). According to ethnicity, the prevalence of suspected Gilbert's syndrome was 5.4%, 5.4%, and 6.8% in Sistani, Fars and Turkmen subjects, respectively. This difference was not significant. The prevalence of suspected Gilbert's syndrome in three ethnicities was higher in males than females and it was statistically significant in Sistani and Fars ethnicities (P<0.05) but not significant in Turkmen ethnicity.
Conclusion: Suspected cases of Gilbert's syndrome were more common in men than women, and more prevalent in the Turkmen ethnic group. |
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Keywords: Prevalence [MeSH], Gilbert's Syndrome [MeSH], Bilirubin [MeSH]
Article ID: Vol23-15 |
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Full-Text [PDF 495 kb]
(11749 Downloads)
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Type of Study: Original Articles |
Subject:
Genetic
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1. Hemmati F, Saki F, Saki N, Haghighat M. Gilbert syndrome in Iran, Fars Province. Ann Saudi Med. 2010 Jan-Feb; 30(1): 84. DOI: 10.4103/0256-4947.59376 [ DOI] [ PubMed] 2. Berrueco R, Alonso-Saladrigues A, Martorell-Sampol L, Català-Temprano A, Ruiz-Llobet A, Toll T, et al. Outcome and toxicities associated to chemotherapy in children with acute lymphoblastic leukemia and Gilbert syndrome. Usefulness of UGT1A1 mutational screening. Pediatr Blood Cancer. 2015 Jul; 62(7): 1195-201. DOI: 10.1002/pbc.25457 [ DOI] [ PubMed] 3. Ehmer U, Kalthoff S, Fakundiny B, Pabst B, Freiberg N, Naumann R, et al. Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation. Hepatology. 2012 Jun; 55(6): 1912-21. DOI: 10.1002/hep.25561 [ DOI] [ PubMed] 4. Shiu TY, Huang HH, Lin HH, Shih YL, Chu HC, Chang WK, et al. Restriction fragment length polymorphism effectively identifies exon 1 mutation of UGT1A1 gene in patients with Gilbert's Syndrome. Liver Int. 2015 Aug; 35(8): 2050-56. DOI: 10.1111/liv.12785 [ DOI] [ PubMed] 5. Harraway JR, George PM. Use of fully denaturing HPLC for UGT1A1 genotyping in Gilbert syndrome. Clin Chem. 2005 Nov; 51(11): 2183-85. DOI: 10.1373/clinchem.2005.054429 [ DOI] [ PubMed] 6. Azlin I, Wong FL, Ezham M, Hafiza A, Ainoon O. Prevalence of uridine glucuronosyl transferase 1A1 (UGT1A1) mutations in Malay neonates with severe jaundice. Malays J Pathol. 2011 Dec; 33(2): 95-100. [ PubMed] 7. Horsfall LJ, Zeitlyn D, Tarekegn A, Bekele E, Thomas MG, Bradman N, et al. Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations. Ann Hum Genet. 2011 Mar; 75(2): 236-46. DOI: 10.1111/j.1469-1809.2010.00638.x [ DOI] [ PubMed] 8. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med. 1995 Nov; 333(18): 1171-75. DOI: 10.1056/NEJM199511023331802 [ DOI] [ PubMed] 9. Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A. 1998 Jul; 95(14): 8170-74. DOI: 10.1073/pnas.95.14.8170 [ DOI] [ PubMed] 10. Radu P, Atsmon J. Gilbert's syndrome--clinical and pharmacological implications. Isr Med Assoc J. 2001 Aug; 3(8): 593-98. [ PubMed] 11. Bakhotmah MA, Gasem AA, Bairotee B. Asymptomatic unconjugated hyperbilirubinemia (Gilbert syndrome) among Saudis in Jeddah. Ann Saudi Med. 1995 Jul; 15(4): 422-23. DOI: 10.5144/0256-4947.1995.422 [ DOI] [ PubMed] 12. Strassburg CP. Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). Best Pract Res Clin Gastroenterol. 2010 Oct; 24(5): 555-71. DOI: 10.1016/j.bpg.2010.07.007 [ DOI] [ PubMed] 13. Erdil A, Kadayifci A, Ates Y, Bagci S, Uygun A, Dagalp K. Rifampicin test in the diagnosis of Gilbert's syndrome. Int J Clin Pract. 2001 Mar; 55(2): 81-83. [ PubMed] 14. Hallal H, Egea JM, Mas P, García MD, Pérez-Cuadrado E, Carballo F. A shortened, 2-hour rifampin test: a useful tool in Gilbert's syndrome. Gastroenterol Hepatol. 2006 Feb; 29(2): 63-65. DOI: 10.1016/s0210-5705(06)71601-6 [ DOI] [ PubMed] 15. Kamal S, Abdelhakam S, Ghoraba D, Massoud Y, Abdel Aziz K, Hassan H, et al. The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study. BMC Gastroenterol. 2019 Feb; 19(1): 22. DOI: 10.1186/s12876-019-0931-2 [ DOI] [ PubMed] 16. Méndez L, Lagoa M, Quiroga T, Margozzini P, Azócar L, Molina HR, et al. [Prevalence of Gilbert syndrome and its genetic determinants in Chile]. Rev Med Chil. 2013 Oct; 141(10): 1266-74. DOI: 10.4067/S0034-98872013001000005 [Article in Spanish] [ DOI] [ PubMed] 17. Wagner KH, Shiels RG, Lang CA, Seyed Khoei N, Bulmer AC. Diagnostic criteria and contributors to Gilbert's syndrome. Crit Rev Clin Lab Sci. 2018 Mar; 55(2): 129-39. DOI: 10.1080/10408363.2018.1428526 [ DOI] [ PubMed] 18. Sieg A, Arab L, Schlierf G, Stiehl A, Kommerell B. [Prevalence of Gilbert's syndrome in Germany]. Dtsch Med Wochenschr. 1987 Jul; 112(31-32): 1206-8. DOI: 10.1055/s-2008-1068222 [Article in German] [ DOI] [ PubMed] |
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Aliarab A, Yaghmaei B, Ghaderian S M H, Kalavi M, Khoshnia M, Roshandel G, et al . Prevalence of suspected Gilbert’s syndrome in Golestan province, northern Iran (2014). J Gorgan Univ Med Sci 2021; 23 (1) :116-120 URL: http://goums.ac.ir/journal/article-1-3345-en.html
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