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:: Volume 19, Issue 3 (10-2017) ::
J Gorgan Univ Med Sci 2017, 19(3): 24-31 Back to browse issues page
Combination thrapy of hydroalcoholic extract of Pistacia atlantica kurdica and fluvoxamine on spatial memory of immobilization rat
M Mohammadzadeh1 , F Babaeifar * 2, F Babaei1
1- Assistant Professor, Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
2- M.Sc Student in Animal Physiology, Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran , fatemehbabaei706@yahoo.com
Abstract:   (12806 Views)
Background and Objective: Oxidative stress causes disorder in the brain processes including memory. Pistacia atlantica kurdica (pistachio) contains antioxidant compounds, oleic and linoleic acid. Fluvoxamine is an antidepressant medicine which inhibits serotonin reuptake. This study was done to determine the effect of hydroalcoholic extract of pistachio and fluvoxamine on spatial memory of male rats under immobilization stress.
Methods: This experimental study was done on 30 adult male Wistar rats in 5 groups (n=6). The control group was not under immobilization stress. Animals in the stress group were just under immobilization stress. Animals in the pistachio group were under immobilization stress and were received 400 mg/kg/bw hydroalcoholic extract of pistachio. Animals in the fluvoxamine group under immobilization stress were received 120 mg/kg/bw fluvoxamine. Animals under immobilization stress, in the pistachio plus fluvoxamine group were received 400 mg/kg/bw hydroalcoholic extract of pistachio and fluvoxamine 120 mg/kg/bw. The radial arm maze test was used for evaluation of spatial memory. After the animals’ decapitation, the malondialdehyde and catalase level in hippocampus and the serum level of corticosterone and blood glucose were measured.
Results: The stress significantly increased the time of reaching to target, malondialdehyde, corticoestron and blood glucose level, and reduced the catalase in stress group in comprasion with controls (P<0.05). In the pistachio and the pistachio+fluvoxamine treated groups, the time of reaching to target, malondialdehyde, corticoestron and blood glucose level significantly reduced and the catalase level significantly increased in comprasion with stress group (P<0.05) but fluvoxamine significantly increased the time of reaching to target, malondialdehyde and blood glucose, and reduced the corticoestron and catalase in compared to controls (P<0.05).
Conclusion: The immobilization stress led to attenuation of spatial memory and the fluvoxamine administration as an antidepressant drug caused to deterioration of memory,while the treatment with pistachio extract lead to improve the memory.
Keywords: Pistacia atlantica kurdica, Fluvoxamine, Immobilization stress, Spatial memory, Rat
Full-Text [PDF 404 kb] [English Abstract]   (14755 Downloads) |   |   Abstract (HTML)  (1180 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
References
1. Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P. Fish, docosahexaenoic acid and Alzheimer's disease. Prog Lipid Res. 2009 Sep; 48(5): 239-56. doi:10.1016/j.plipres.2009.04.001
2. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol. 2011 Sep; 667(1-3): 222-9. doi:10.1016/j.ejphar.2011.05.012
3. Zamani Z, Reisi P, Alaei H, PilehvarianA. [Effect of royal jelly on improving passive avoidance learning and spatial learning and memory in rats]. J Shahid Sadoughi Univer of Med Scien. 2012; 20(2): 211-19. [Article in Persian]
4. Poleszak E, Wla P, Kedzierska E, Nieoczym D, Wyska E, Szymura-Oleksiak J, et al. Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine. Pharmacol Rep. 2006 Sep-Oct; 58(5): 746-52.
5. Van Ast VA, Cornelisses S, Marin MF, Ackermann S, Garfinkel S, Abercrombie HC. Modulatory mechanisms of cortisol effects on emotional learning and memory: Novel perspectives. Psyendocrinology. 2013 Sep; 38(9): 1874-82. doi:10.1016/j.psyneuen.2013.06.012
6. Ameri F, Vahabi MR, Khatoon Abadi A, Andalibi L. [On the relevance of medicinal plants consumers in Iran: investigating statistics for consumers, states of consumption, informative and source area]. Teb va Tazkieh. 2013; 22(3): 37-42. [Article in Persian]
7. Ben Hamed S, Lefi E. Dynamics of growth and phytomass allocation in seedlings of Pistacia atlantica desf versus Pistacia vera L under salt stress. International Journal of Agronomy and Agricultural Research. 2015; 6(1): 16-27.
8. Yamauchi M, Miyara T, Matsushima T, Imanishi T. Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. Brain Res. 2006 Jan; 1067(1): 164-9. doi:10.1016/j.brainres.2005.10.075
9. Hashemi S S, Jelodar G A, Rafati A. [Investigating the effects of Fluoxetine on Cortisol and thyroid hormone levels in rats]. J Arak Univ Med Sci. 2014; 17(2): 82-89. [Article in Persian]
10. Tamadonfard Z, Sepehrara L, Johari H. [The effect of nigella sativa extract on learning and spatial memory of adult male rats]. Pars Journal of Medical Sciences. 2014; 12(1): 29-37. [Article in Persian]
11. Rashidi S, Askari N, Abbasnejad M. Anxiolytic-like effect of Pistacia atlantica fruit in intact and gonadectomized rats subjected to chronic stress. J Occu Health Epidemiol. 2014; 3(3): 152-59.
12. Mozafar A, Keshavarz M, Zareian P, Johary H, Kargarjahromi H, Hoseini S. [The effect of immobilization stress on the HPG axis (hypothalamic-pituitary-gonad) hormones and the number of spermatogonia]. J Fasa Uni Med Sci. 2013; 3(3): 280-84. [Article in Persian]
13. Bahrebar M, Mirzaei A, Mantegheyan E, Bahrebar A. [In vivo and in vitro antioxidant activity of hydro-alcoholic extract of Pistacia Atlantica]. Armaghane Danesh. 2013; 17(6): 540-51. [Article in Persian]
14. Mokhtari M, Shariatie M, Tavakoli F. [Effect of fluvoxamine on concentration of testosterone, FSH, LH and histological changes in testis in adult male rat]. Feyz. 2007; 10(4): 31-36. [Article in Persian]
15. Hosseini M, Shemshaki A, Saghebjoo M, Gharari Arefi R. [Effect of aerobic training and Pistacia atlantica extract consumption on plasma levels of lipocalin-2 and insulin resistance index in Streptozotocin-induced diabetic rats]. Horizon Med Sci. 2016; 22(1): 27-33. [Article in Persian]
16. Braslasu ED, Bradatan C, Cornila M, Savulescu I, Cojmaleata R, Braslasu MC. Normal blood glucose in white wistar rat and its changes following anesthesia. Lucari Stiintifice Medicina Veterinara. 2007; 40: 120-23.
17. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 1990; 186: 407-21.
18. Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-26.
19. Pawar VS, Hugar S. Adaptogenic activity of Trigonella foenumgraecum (Linn) seeds in rodents exposed to anoxia and immobilization stress. Asian Pac J Trop Biomed. 2012; 2(1): S208-S211. https://doi.org/10.1016/S2221-1691(12)60161-0
20. Moosavi M, Naghdi N, Maghsoudi N, Zahedi Asl S. Insulin protects against stress-induced impairments in water maze performance. Behav Brain Res. 2007 Jan; 176(2): 230-36. doi:10.1016/j.bbr.2006.10.011
21. LI SQ, SU ZH, PENG JB, ZOU ZM, YU CY. In vitro and in vivo antioxidant effects and the possible relationship between the antidepression efficacy of traditional chinese medicine formulation chaihu Shugan San. Chin J Nat Med. 2010; 8(5): 353-61. https://doi.org/10.1016/S1875-5364(10)60042-8
22. Abdel-Salam OME, Morsy SMY, Sleem AA. The effect of different antidepressant drugs of oxidative stress after lipopolysaccharide administration in mice. EXCLI Journal. 2011; 10: 290-302. http://dx.doi.org/10.17877/DE290R-5131
23. Afshari M, Farokhi F, Ebrahimi S, Larti B. [Histopathological study of the hypocampal neurons in male rats treatedwith citalopram and aqueous extract of saffron]. J Rafsanjan Univ Med Sci. 2013; 12(1): 27-34. [Article in Persian]
24. Rahimi Asl F, Farbood Y, Sarkaki AR, Hosseini SE. [Effect of gallic acid on passive avoidance memory under brain ischemia conditions in mature female rats]. Horizon of Medical Sciences. 2014; 20(1): 23-27. [Article in Persian]
25. Ghasemloo E, Rahnema M, Bigdeli M. [Brain edema and neurologic deficits in rat stroke model: the effect of hydroalcoholic extract of Salvia officinalis]. J Fasa Univ Med Sci. 2015; 5(3): 378-86. [Article in Persian]
26. Hatamnia AA, Abbaspour N, Darvishzadeh R. Antioxidant activity and phenolic profile of different parts of Bene (Pistacia atlantica subsp. kurdica) fruits. Food Chem. 2014 Feb; 145: 306-11. doi:10.1016/j.foodchem.2013.08.031
27. Hamdan II, Afifi FU. Studies on the in vitro and in vivo hypoglycemic activities of some medicinal plants used in treatment of diabetes in Jordanian traditional medicine. J Ethnopharmacol. 2004 Jul; 93(1): 117-21.
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Mohammadzadeh M, Babaeifar F, Babaei F. Combination thrapy of hydroalcoholic extract of Pistacia atlantica kurdica and fluvoxamine on spatial memory of immobilization rat . J Gorgan Univ Med Sci 2017; 19 (3) :24-31
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Volume 19, Issue 3 (10-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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