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:: Volume 19, Issue 3 (10-2017) ::
J Gorgan Univ Med Sci 2017, 19(3): 47-51 Back to browse issues page
Prevalence of fatty liver in overweight, obese and normal children
M Tavakoli1 , M Sobhani Shahmirzadi * 2, H Zaeri3 , A ZhianiAsgharzadeh4 , M Zare4 , MH Gharib5 , Gh Roshandel6
1- Resident in Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant Professor, Pediatric Gastroenterologist, Children and Neonates Research Center, Golestan University of Medical Sciences, Gorgan, Iran , sobha48@yahoo.com
3- Assistant Professor, Pediatric Endocrinologist, Children and Neonates Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Medical Student, Children and Neonates Research Center, Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
5- Assistant Professor, Radiologist, Children and Neonates Research Center, Golestan University of Medical Sciences, Gorgan, Iran
6- Assistant Professor, Epidemiologist, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (14523 Views)
Background and Objective: Nonalcoholic fatty liver disease is the most common cause of liver disease worldwide and it is defined as a disorder of excess fat accumulation in the liver. This study was done to determine the prevalence of fatty liver among overweight, obese and normal children.
Methods: This historical cohort study was conducted on 90 children ages 5 to 13 years old in Taleghani pediatric theching hospital in Gorgan, north of Iran during 2014. Subjects according to Body Mass Index (BMI) classified into obese (95%>BMI), over weight (85-95% BMI) and normal (5-85% BMI). Childern were matched for age and sex. Liver enzymes (ALT Alanine aminotransferase and AST (Aspartate aminotransferase) and lipid profile includingTriglyceride: TG (High Density Lipoprotein: HDL and (Low Density Lipoprotein: LDL were measured and fatty liver evaluated based on sonographic parameters by a radiologist who didnot know children's BMI.
Results: The prevalence of fatty liver was 23.3% in obese children that was non- significantly higher than normal (16.7%) and over weight (16.7%) children. The prevalence of fatty liver was not significantly different between two sexes. AST was significantly higher in children with normal BMI in compared to obese and over weight children (P<0.05). The highest and lowest level of cholesterol was seen in obese and normal children (P<0.05).
Conclusion: This study showed that the prevalence of fatty liver non-significantly was higher in obese children in comparision with normal and over weight children.
Keywords: Fatty liver, BMI, Liver enzymes, Cholesterol, Child
Full-Text [PDF 226 kb] [English Abstract]   (14322 Downloads) |   |   Abstract (HTML)  (1007 Views)  
Type of Study: Original Articles | Subject: Pediatric
References
1. Zimmermann E, Gamborg M, Holst C, Baker JL, Sørensen TIA, Berentzen TL. Body mass index in school-aged children and the risk of routinely diagnosed non-alcoholic fatty liver disease in adulthood: a prospective study based on the Copenhagen School Health Records Register. BMJ Journal. 2015; 5(4): 1-9. http://dx.doi.org/10.1136/bmjopen-2014-006998
2. Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One. 2015 Oct; 10(10): e0140908. doi:10.1371/journal.pone.0140908
3. Lonardo A, Bellentani S, Argo CK, Ballestri S, Byrne CD, Caldwell SH, et al. Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups. Dig Liver Dis. 2015 Dec; 47(12): 997-1006. doi:10.1016/j.dld.2015.08.004
4. Molleston JP, Schwimmer JB, Yates KP, Murray KF, Cummings OW, Lavine JE, et al. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr. 2014 Apr; 164(4): 707-13. doi:10.1016/j.jpeds.2013.10.071
5. Bonci E, Chiesa C, Versacci P, Anania C, Silvestri L, Pacifico L. Association of nonalcoholic fatty liver disease with subclinical cardiovascular changes: a systematic review and meta-analysis. Biomed Res Int. 2015; 2015: 213737. doi:10.1155/2015/213737
6. Rehm JL, Connor EL, Wolfgram PM, Eickhoff JC, Reeder SB, Allen DB. Predicting hepatic steatosis in a racially and ethnically diverse cohort of adolescent girls. J Pediatr. 2014 Aug; 165(2): 319-25. doi:10.1016/j.jpeds.2014.04.019
7. Nobili V, Alkhouri N, Alisi A, Della Corte C, Fitzpatrick E, Raponi M, et al. Nonalcoholic fatty liver disease: a challenge for pediatricians. JAMA Pediatr. 2015 Feb; 169(2): 170-76. doi:10.1001/jamapediatrics.2014.2702
8. Guijarro de Armas MG, Monereo Megías S, Navea Aguilera C, Merino Viveros M, Vega Piñero MB. [Non-alcoholic fatty liver in children and adolescents with excess weight and obesity]. Med Clin (Barc). 2015 Jan; 144(2): 55-58. doi:10.1016/j.medcli.2014.02.018 [Article in Spanish]
9. Saffari F, Jalilolghadr S, Esmailzadehha N, Azinfar P. Metabolic syndrome in a sample of the 6- to 16-year-old overweight or obese pediatric population: a comparison of two definitions. Ther Clin Risk Manag. 2012; 8: 55-63. doi:10.2147/TCRM.S26673
10. Dietz WH. Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics. 1998 Mar; 101(3 Pt 2): 518-25.
11. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003 Mar; 107(10): 1448-53.
12. Maffeis C, Moghetti P, Grezzani A, Clementi M, Gaudino R, Tatò L. Insulin resistance and the persistence of obesity from childhood into adulthood. J Clin Endocrinol Metab. 2002 Jan; 87(1): 71-76.
13. Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr. 2012 May; 54(5): 700-13. doi:10.1097/MPG.0b013e318252a13f
14. Curtis VA, Carrel AL, Eickhoff JC, Allen DB. Gender and race influence metabolic benefits of fitness in children: a cross-sectional study. Int J Pediatr Endocrinol. 2012; 2012(1): 4. doi:10.1186/1687-9856-2012-4
15. Moradhaseli F, Ansari A, Zahedi M J, Hayatbakhsh Abbasi M, Ahmadi J, Darvish Moghaddam S. [Correlation of mesenteric fat thickness and liver fat accumulation in non-alcoholic fatty liver disease]. Iran South Med J. 2010; 13(3): 180-89. [Article in Persian]
16. Kelishadi R, Cook SR, Adibi A, Faghihimani Z, Ghatrehsamani S, Beihaghi A, et al. Association of the components of the metabolic syndrome with non-alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents. Diabetol Metab Syndr. 2009 Dec; 1: 29. doi:10.1186/1758-5996-1-29
17. Alkassabany YM, Farghaly AG, El-Ghitany EM. Prevalence, risk factors, and predictors of nonalcoholic fatty liver disease among schoolchildren: a hospital-based study in Alexandria, Egypt. Arab J Gastroenterol. 2014 Jun; 15(2): 76-81. doi:10.1016/j.ajg.2014.05.002
18. Santomauro M, Paoli-Valeri M, Fernández M, Camacho N, Molina Z, Cicchetti R, et al. [Non-alcoholic fatty liver disease and its association with clinical and biochemical variables in obese children and adolescents: effect of a one-year intervention on lifestyle]. Endocrinol Nutr. 2012 Jun-Jul; 59(6): 346-53. doi:10.1016/j.endonu.2012.05.002 [Article in Spanish]
19. Papandreou D, Karabouta Z, Pantoleon A, Rousso I. Investigation of anthropometric, biochemical and dietary parameters of obese children with and without non-alcoholic fatty liver disease. Appetite. 2012 Dec; 59(3): 939-44. doi:10.1016/j.appet.2012.09.006
20. Ezzat WM, Ragab S, Ismail NA, Elhosary YA, Abd ElBaky AMN, Farouk H, et al. Frequency of non-alcoholic fatty liver disease in overweight/obese children and adults: Clinical, sonographic picture and biochemical assessment. J Genet Eng Biotechnol. 2012; 10(2): 221-27. https://doi.org/10.1016/j.jgeb.2012.05.006
21. Radetti G, Kleon W, Stuefer J, Pittschieler K. Non-alcoholic fatty liver disease in obese children evaluated by magnetic resonance imaging. Acta Paediatr. 2006 Jul; 95(7): 833-37.
22. Torun E, Özgen T, Gökçe S, Aydın S, Cesur Y. Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. J Clin Res Pediatr Endocrinol. 2014 Mar; 6(1): 34-39. doi:10.4274/Jcrpe.1155
23. Zhu Y, Shao Z, Jing J, Ma J, Chen Y, Li X, et al. Body mass index is better than other anthropometric indices for identifying dyslipidemia in Chinese children with obesity. PLoS One. 2016; 11(3): e0149392. doi:10.1371/journal.pone.0149392
24. Elizondo-Montemayor L, Ugalde-Casas PA, Lam-Franco L, Bustamante-Careaga H, Serrano-González M, Gutiérrez NG, et al. Association of ALT and the metabolic syndrome among Mexican children. Obes Res Clin Pract. 2014 Jan-Feb; 8(1): e79-87. doi:10.1016/j.orcp.2012.08.191
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Tavakoli M, Sobhani Shahmirzadi M, Zaeri H, ZhianiAsgharzadeh A, Zare M, Gharib M et al . Prevalence of fatty liver in overweight, obese and normal children . J Gorgan Univ Med Sci 2017; 19 (3) :47-51
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Volume 19, Issue 3 (10-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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