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:: Volume 19, Issue 1 (3-2017) ::
J Gorgan Univ Med Sci 2017, 19(1): 103-106 Back to browse issues page
Evaluation of IgG and IgM antibodies against Varicella zoster virus in children with acute lymphoblastic leukemia
A Ghassemi1 , Z Badiee1 , H Farhangi1 , A Banihashem2 , SJ Sayedi * 3, R Ghodsi4 , A Mokhtari5 , A Attaranzadeh6
1- Associate Professor, Department of Pediatric Hematology & Oncology, Mashhad University of Medical Sciences, Mashhad, Iran
2- Professor, Department Pediatric Hematology & Oncology, Mashhad University of Medical Sciences, Mashhad, Iran
3- Associate Professor, Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran , sayedij@mums.ac.ir
4- Associate Professor, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Pediatrician, Kashmar, Iran
6- Fellowship & Cytogentics, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (13486 Views)

Background and Objective: Varicella zoster virus (VZV) can cause a moderate disease in children, but with high risk of serious disease or death in children with acute lymphoblastic leukemia (ALL) Vaccination from infection can be safe, immunogenic, and effective in children with leukemia. This study was done to evaluate the IgG and IgM antibodies against VZV in children with acute lymphoblastic leukemia.

Methods: The descriptive-analytic study was performed on 66 children who were on chemotherapy in Dr Shigh hospital in Mashhad, Iran during 2012. Patients were receivied VZV vaccine. The title negative or positive serum sample for IgG-anti-VZV avidity was determined by using a test kit before and after injection of vaccines VZV for considering the efficacy of vaccines on pediatric patients.

Results: Title serum sample IgG were positive in 32.6% patients, these children have history of chicken pox disease and to be safe against of VZV. 78.3% of the patients were negative for IgG antibody and sensitive against of VZV.

Conclusion: Children with ALL receiving chemotherapy are sensitive to chicken pox disease according to negative IgG titer against VZV.
Keywords: Acute lymphoblastic leukemia, Varicella zoster virus, Antibody, Child
Full-Text [PDF 179 kb] [English Abstract]   (16123 Downloads) |   |   Abstract (HTML)  (1459 Views)  
Type of Study: Short Communication | Subject: Pediatric
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Ghassemi A, Badiee Z, Farhangi H, Banihashem A, Sayedi S, Ghodsi R, et al . Evaluation of IgG and IgM antibodies against Varicella zoster virus in children with acute lymphoblastic leukemia. J Gorgan Univ Med Sci 2017; 19 (1) :103-106
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Volume 19, Issue 1 (3-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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