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:: Volume 19, Issue 1 (3-2017) ::
J Gorgan Univ Med Sci 2017, 19(1): 14-19 Back to browse issues page
Effect of iron oxide Nanoparticles coated with chitosan on renal functional indeces in rats
M Salehi1 , S Fatahian * 2, K Shahanipour3
1- M.Sc Student in Biochemisty, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2- Assistant Professor, Department of Biochemisty, Falavarjan Branch, Islamic Azad University, Isfahan, Iran , fatahian@iaufala.ac.ir
3- Assistant Professor, Department of Biochemisty, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Abstract:   (10578 Views)

Background and Objective: Iron oxide nanoparticles have wide applications such as MRI contrast agent and drug delivery. Nevertheless, their effects on human health have not been fully investigated yet. After cellulose, chitin is one of the most abundant organic materials in nature which is widely used in food industry, cosmetics, agriculture, medicine and the environment. This study was done to evaluate the effect of iron oxide nanoparticles coated with chitosan on renal functional indeces in rat.

Methods: In this experimental study, 60 adult female Wistar rats were allocated into 10 equal groups. Concentrations of 50, 100 and 150 mg/kg/bw from chitosan, iron oxide nanoparticles and chitosan coated nanoparticles were intraperitoneally injected into 9 groups and animals in control group were received normal saline. Blood samples were collected directly from the rat heart in the days 15 and 30 post after injection and renal functional indeces including urea, creatinine, uric acid, sodium, potassium and total protein were measured.

Results: There were no significant differences in the level of urea, creatinine, uric acid, sodium, potassium and total protein in the groups whom received chitosan-coated iron oxide nanoparticles compared to control. There was no mortality during the study time.

Conclusion: Short-term using of iron oxide nanoparticles coated with chitosan does not create any toxicity in the rat kidney.

Keywords: Toxicity, Chitosan, Nanoparticles, Iron oxide, Urea, Creatinine, Kidney, Rat
Full-Text [PDF 307 kb] [English Abstract]   (14366 Downloads) |   |   Abstract (HTML)  (910 Views)  
Type of Study: Original Articles | Subject: Nanobiotecnology
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Salehi M, Fatahian S, Shahanipour K. Effect of iron oxide Nanoparticles coated with chitosan on renal functional indeces in rats. J Gorgan Univ Med Sci 2017; 19 (1) :14-19
URL: http://goums.ac.ir/journal/article-1-3013-en.html

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Volume 19, Issue 1 (3-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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