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:: Volume 18, Issue 4 (12-2016) ::
J Gorgan Univ Med Sci 2016, 18(4): 69-73 Back to browse issues page
Association of VEGF gene +405C/G polymorphism with the risk of breast cancer in northern Iran
H Karimi-Rouzbahani1 , F Mashayekhi * 2, H Saeedi-Saedi3
1- M.Sc Student in Genetic, University of Guilan, University Campus, Rasht, Iran
2- Professor, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran , mashayekhi@guilan.ac.ir
3- Associate Professor, Radiotherapy and Oncology Specialist, Faculty of Medicine, Guilan Univresity of Medical Sciences, Rasht, Iran
Abstract:   (11331 Views)

Background and Objective: Breast cancer is a cancer in women with high prevalancy worldwide. Vascular endothelial growth factor (VEGF) is one of the most important Pro-angiogenic factors. +405C/G is one of the common VEGF polymorphism which may have an impact on the level of gene expression and over loading of gene products. This study was done to evaluate the association between VEGF +405C/G gene polymorphism and breast cancer risk in north of Iran.

Methods: This case-control study was carried out on 50 patients with breast cancer and 50 normal aged-matched controls in north of Iran. Genomic DNA was extracted from peripheral blood cells. To determine the genotype of +405 C/G VEGF gene polymorphism, PCR-RFLP method was used.

Results: The prevalence of genotypic frequencies of GG, GC and CC in controls were 42%, 48% and 10%, respectively  and in patients were 22%, 46% and 32%, respectively (P<0.05). The +405C allele was considered as a risk factor in breast cancer (P<0.05).

Conclusion: It seems +405 C/G VEGF gene polymorphism may be associated with the breast cancer in northern Iran.
Keywords: Breast cancer, Polymorphism VEGF, +405C/G gene, Iran
Full-Text [PDF 172 kb] [English Abstract]   (13633 Downloads) |   |   Abstract (HTML)  (1354 Views)  
Type of Study: Original Articles | Subject: Genetic
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Karimi-Rouzbahani H, Mashayekhi F, Saeedi-Saedi H. Association of VEGF gene +405C/G polymorphism with the risk of breast cancer in northern Iran. J Gorgan Univ Med Sci 2016; 18 (4) :69-73
URL: http://goums.ac.ir/journal/article-1-2958-en.html
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Volume 18, Issue 4 (12-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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