Effect of endurance swimming training on serum homocysteine level and atherogenic index in rats

Kordi , MR; Borumand , MA; Rabbani , Sh; Alimoradi Sheikhha  , N; Mazraeh , A; Siuf , M

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Volume 18, Issue 4 (12-2016)

J Gorgan Univ Med Sci 2016, 18(4): 42-48

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Effect of endurance swimming training on serum homocysteine level and atherogenic index in rats

MR Kordi¹

, MA Borumand²

, Sh Rabbani³

, N Alimoradi Sheikhha⁴

, A Mazraeh ^*

⁵, M Siuf⁶

1- Associate Professor, Department of Sport Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
2- Associate Professor, Department of Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3- Veterinary Medicine, Department of Experimental Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
4- M.Sc in Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
5- M.Sc in Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran , ahmad.mazrae@yahoo.com
6- M.Sc in Exercise Physiology, Department of Physical Education, Firoozabad Branch, Islamic Azad University, Meymand, Iran

Abstract: (12151 Views)

Background and Objective: Homocysteine and atherogenic index are significant and independent risk factors for cardiovascular diseases. This study was done to determine the effect of 10 weeks endurance swimming training on serum homocysteine level and atherogenic index in rats.

Methods: In this experimental study, 20 adult male Wistar rats (180±20 g) were randomly allocated into control (n=10) and experimental (n=10) groups. Animals in experimental group swam ten weeks of endurance training (5 days a week, for 60 minutes a day) with a 5% body weight load attached to the tail. At the end of 10 weeks and after the last of training session and 12 hours of fasting animals were sacrificed. Blood samples were taken and serum homocysteine level, atherogenic index and
NON-HDL-cholesterol were measured.

Results: Serum homocysteine level, atherogenic index and NON-HDL-cholesterol of animals significantly reduced in the experimental group compared to the controls (P<0.05).

Conclusion: Ten weeks of endurance swimming training with low to moderate intensity improves homocysteine level and atherogenic index in animal model.

Keywords: Endurance swimming training, Homocysteine, Atherogenic index, NON-HDL-cholesterol, Rat

Full-Text [PDF 223 kb] [English Abstract] (13610 Downloads) | | Abstract (HTML) (1166 Views)

Type of Study: Original Articles | Subject: Exercise Physiology

References

1. Palmefors H, DuttaRoy S, Rundqvist B, Börjesson M. The effect of physical activity or exercise on key biomarkers in atherosclerosis--a systematic review. Atherosclerosis. 2014 Jul; 235(1): 150-61. doi:10.1016/j.atherosclerosis.2014.04.026

2. Ghahramanloo E, Midgley AW, Bentley DJ. The effect of concurrent training on blood lipid profile and anthropometrical characteristics of previously untrained men. J Phys Act Health. 2009 Nov; 6(6): 760-6.

3. e Silva Ade S, da Mota MP. Effects of physical activity and training programs on plasma homocysteine levels: a systematic review. Amino Acids. 2014 Aug; 46(8): 1795-804. doi:10.1007/s00726-014-1741-z

4. Kanthe PS, Patil BS, Bagali S, Deshpande A, Shaikh GB, Aithala M. Atherogenic index as a predictor of cardiovascular risk among women with different grades of obesity. Int J Collab Res Intern Med Public Health. 2012; 4(10): 1767-74.

5. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002 Dec; 106(25): 3143-421.

6. Duncan GE, Perri MG, Anton SD, Limacher MC, Martin AD, Lowenthal DT, et al. Effects of exercise on emerging and traditional cardiovascular risk factors. Prev Med. 2004 Nov; 39(5): 894-902.

7. de Ferranti SD, Rifai N. C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovasc Pathol. 2007 Jan-Feb; 16(1): 14-21.

8. Joubert LM, Manore MM. Exercise, nutrition, and homocysteine. Int J Sport Nutr Exerc Metab. 2006 Aug; 16(4): 341-61.

9. Cheng Z, Yang X, Wang H. Hyperhomocysteinemia and endothelial dysfunction. Curr Hypertens Rev. 2009 May; 5(2): 158-65.

10. Randeva HS, Lewandowski KC, Drzewoski J, Brooke-Wavell K, O'Callaghan C, Czupryniak L, et al. Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Oct; 87(10): 4496-501.

11. Gaume V, Figard H, Mougin F, Guilland JC, Alberto JM, Gueant JL, et al. Effect of a swim training on homocysteine and cysteine levels in rats. Amino Acids. 2005 May; 28(3): 337-42.

12. Bailey DM, Davies B, Baker J. Training in hypoxia: modulation of metabolic and cardiovascular risk factors in men. Med Sci Sports Exerc. 2000 Jun; 32(6): 1058-66.

13. Tonello L, Godinho Ribeiro DB, Asano RY, da Silveira JM, de Miranda EF. Aerobic training and lipid profile of hypothyroid rats. Rev Andal Med Deporte. 2013; 6(2): 47-51. doi:10.1016/S1888-7546(13)70034-0

14. Nayanatara AK, Nagaraja HS, Anupama BK. The effect of repeated swimming stress on organ weights and lipid peroxidation in rats. Thai Journal of Physiological Sciences. 2005 Apr; 18(1): 3-9.

15. Medeiros A, Oliveira EM, Gianolla R, Casarini DE, Negrão CE, Brum PC. Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats. Braz J Med Biol Res. 2004 Dec; 37(12): 1909-17.

16. Teixeira KR, Silva ME, Neves LX, dos Santos RC, Pedrosa ML, Haraguchi FK. Whey protein improves HDL/non-HDL ratio and body weight gain in rats subjected to the resistance exercise. Braz Arch Biol Technol. 2012; 55(6): 943-50. http://dx.doi.org/10.1590/S1516-89132012000600019

17. Cooper AR, Kendrick A, Stansbie D, Sargent D, West J. Plasma homocysteine in sedentary men: influence of moderately intense exercise. Cardiovascular Reviews and Reports. 2000; 21: 371-74.

18. Gelecek N, Teoman N, Ozdirenc M, Pinar L, Akan P, Bediz C, Kozan O. Influences of acute and chronic aerobic exercise on the plasma homocysteine level. Ann Nutr Metab. 2007; 51(1): 53-8.

19. de Jong N, Chin A Paw MJ, de Groot LC, Rutten RA, Swinkels DW, Kok FJ, et al. Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning. Am J Clin Nutr. 2001 Feb; 73(2): 338-46.

20. Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, et al. Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study. Eur J Appl Physiol. 2006 Nov; 98(4): 394-401.

21. Herrmann M, Wilkinson J, Schorr H, Obeid R, Georg T, Urhausen A, et al. Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers. Clin Chem Lab Med. 2003 Nov; 41(11): 1525-31.

22. Burneiko RC, Diniz YS, Galhardi CM, Rodrigues HG, Ebaid GM, Faine LA, et al. Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses. Food Chem Toxicol. 2006 Jul; 44(7): 1167-72.

23. Baptista S, Piloto N, Reis F, Teixeira-de-Lemos E, Garrido A, Dias A, et al. Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation. Acta physiologica Hungarica. 2008; 95(4): 365-81.

24. Ghanbari-Niaki A, Khabazian BM, Hossaini-Kakhak SA, Rahbarizadeh F, Hedayati M. Treadmill exercise enhances ABCA1 expression in rat liver. Biochem Biophys Res Commun. 2007 Oct; 361(4): 841-6.

25. Thompson PD, Rader DJ. Does exercise increase HDL cholesterol in those who need it the most? Arterioscler Thromb Vasc Biol. 2001; 21(7): 1097-8.

26. Horowitz JF, Klein S. Lipid metabolism during endurance exercise. Am J Clin Nutr. 2000 Aug; 72(2 Suppl): 558S-63S.

27. Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, et al. Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med. 2007 May; 167(10): 999-1008.

28. Guerra RL, Prado WL, Cheik NC, Viana FP, Botero JP, Vendramini RC, et al. Effects of 2 or 5 consecutive exercise days on adipocyte area and lipid parameters in Wistar rats. Lipids Health Dis. 2007 Jul; 6: 16.

29. Kelley GA, Kelley KS. Effects of aerobic exercise on non-high-density lipoprotein cholesterol in children and adolescents: a meta-analysis of randomized controlled trials. Prog Cardiovasc Nurs. 2008; 23(3): 128-32.

30. Durstine JL, Grandjean PW, Cox CA, Thompson PD. Lipids, lipoproteins, and exercise. J Cardiopulm Rehabil. 2002 Nov-Dec; 22(6): 385-98.

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Kordi M, Borumand M, Rabbani S, Alimoradi Sheikhha N, Mazraeh A, Siuf M. Effect of endurance swimming training on serum homocysteine level and atherogenic index in rats. J Gorgan Univ Med Sci 2016; 18 (4) :42-48
URL: http://goums.ac.ir/journal/article-1-2954-en.html

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