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:: Volume 18, Issue 4 (12-2016) ::
J Gorgan Univ Med Sci 2016, 18(4): 9-15 Back to browse issues page
Effect of Ducrosia anethifolia (Dc.) Boiss essential oil on spatial learning and memory in rats
M Abbasnejad * 1, A Mostafavi2 , R Kooshki3 , P Hamzenejad4 , S Esmaeili-Mahani5
1- Professor, Deptartment of Biology, Shahid Bahonar University of Kerman, Kerman, Iran , mabbas@uk.ac.ir
2- Professor, Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran
3- Ph.D in Animal Phisiology, Deptartment of Biology, Shahid Bahonar University of Kerman, Kerman, Iran
4- M.Sc in Animal Phisiology, Deptartment of Biology, Shahid Bahonar University of Kerman, Kerman, Iran
5- Associate Professor, Deptartment of Biology, Shahid Bahonar University of Kerman, Kerman, Iran
Abstract:   (11383 Views)

Background and Objective: Ducrosia anethifolia (Dc.) is a medicinal odor plant contains CNS effective compounds which has been used in Iranian traditional medicine. This study was done to determine the effect of Ducrosia anethifolia (Dc.) Boiss essential oil on spatial learning and memory in adult male rats.

Methods: In this experimental study, 35 wistar adult male rats were randomly allocated into the five groups (n=7) including: control, sham (injected vehicle) and Ducrosia anethifolia (Dc.) Boiss essential oil groups 0.125, 0.25 and 0.5ml/kg/bw, intraperitonally during four days. Morris water maze test was used to assess learning and memory.

Results: Ducrosia anethifolia (Dc.) Boiss essential oil (0.5 ml/kg/bw) was significantly increased escape latency in the second and third (P<0.05) as well as forth (P<0.05) days of acquisition test in compare to control group. In addition latency to find the hidden platform was significantly decreased with 0.25 essential oil in all days except first day (P<0.05) and in essential oil- treated rats at 0.125 ml/kg/bw in the second and third days (P<0.05) in compare to the control group.  Time spent and distance travelled in target zone were significantly increased in Ducrosia anethifolia (Dc.) Boiss essential oil -treated rats (0.5ml/kg/bw) in compare to control group (P<0.05).

Conclusion: Intraperental administration of the Ducrosia anethifolia (Dc.) Boiss essential oil at doses of 0.5 and 0.25 ml/kg/bw during four days can improves spatial learning and memory in adult male rats.
Keywords: Ducrosia anethifolia (Dc.) Boiss, Learning, Memory, Morris water maze, Rat
Full-Text [PDF 456 kb] [English Abstract]   (15284 Downloads) |   |   Abstract (HTML)  (1279 Views)  
Type of Study: Original Articles | Subject: Neurosciences
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Abbasnejad M, Mostafavi A, Kooshki R, Hamzenejad P, Esmaeili-Mahani S. Effect of Ducrosia anethifolia (Dc.) Boiss essential oil on spatial learning and memory in rats. J Gorgan Univ Med Sci 2016; 18 (4) :9-15
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Volume 18, Issue 4 (12-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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