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:: Volume 18, Issue 3 (10-2016) ::
J Gorgan Univ Med Sci 2016, 18(3): 1-6 Back to browse issues page
Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome
T Dabbaghi Ghale1 , F Mohebbi * 2, F Movahed1 , H Pakniat3 , Z Yazdi4
1- Associate Professor, Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Resident in Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. , fmohebbi@qums.ac.ir
3- Assistant Professor, Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran.
4- Associate Professor, Department of Community Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:   (9375 Views)

Background and Objective: Polycystic ovary syndrome (PCOS) is the most endocrine disorder in women. This study was done to determine the effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome.

Methods: This clinical trail study was carried out on forty PCOS women with normal TSH, prolactin, hysterosalpingographies and normal spermograms. The patients in control group were received letrozole 5 mg/d for 5 days starting at day 3 of the cycle. The patients in interventional group were received letrozole 5 mg/d with NAC 1.2 g/d (group II) for 5 days starting at day 3 of the cycle. On 14th day of cycle, transvaginal ultrasonography was performed to evaluate endometrial thickness and follicles properties. If mature follicle detected, hCG was injected and timed coitus at 12, 36 and 60 hours later advised. β-hCG level was checked on day 16 after hCG injection.

Results: The mean of endometrial thickness and follicles ovulation in hCG injection day was similar in the two groups. The pregnancy rate was 15% and 20% in control and interventional groups, respectively. This difference was not significant. The mean of follicles number was 1.13% and 1.47% in control and interventional groups, respectively. This difference was not significant.

Conclusion: NAC as an adjuvant to letrozole was not effective for ovulation induction in patients with PCOS.
Keywords: Polycystic ovary syndrome, N-acetyl-cysteine, Ovulation, Letrozole
Full-Text [PDF 198 kb] [English Abstract]   (21176 Downloads) |   |   Abstract (HTML)  (1376 Views)  
Type of Study: Original Articles | Subject: Obstetrics and Gynecology
References
1. Carmina E, Rosato F, Jannì A, Rizzo M, Longo RA. Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. J Clin Endocrinol Metab. 2006 Jan; 91(1):2-6.
2. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005 Mar; 352(12):1223-36.
3. Fritz MA, Speroff L. Clinical Gynecologic Endocrinology and Infertility. 8th ed. Baltimore: Lippincott, Williams & Wilkins. 2011; p:516, 525, 1309.
4. Holzer H, Casper R, Tulandi T. A new era in ovulation induction. Fertil Steril. 2006 Feb; 85(2):277-84.
5. Saha L, Kaur S, Kumar Saha P. N-acetyl cysteine in clomiphene citrate resistant polycystic ovary syndrome: A review of reported outcomes. J Pharmacol Pharmacother. 2013 Jul-Sep; 4(3): 187-91. doi: 10.4103/0976-500X.114597
6. Wentzel P, Thunberg L, Eriksson UJ. Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture. Diabetologia. 1997 Jan; 40(1):7-14.
7. Santini MT, Cametti C, Indovina PL, Peterson SW. Menadione induces changes in the membrane electrical properties associated with downregulation of insulin receptors in human erythrocytes. Exp Hematol. 1998 Jun; 26(6):466-71.
8. Badawy A, Baker El Nashar A, El Totongy M. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertil Steril. 2006 Sep; 86(3):647-50.
9. Kilic-Okman T, Kucuk M. N-acetyl-cysteine treatment for polycystic ovary syndrome. Int J Gynaecol Obstet. 2004 Jun; 85(3):296-7.
10. Borgström L, Kågedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986; 31(2):217-22.
11. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004 Jan; 81(1):19-25.
12. Rizk AY, Bedaiwy MA, Al-Inany HG. N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome. Fertil Steril. 2005 Feb; 83(2):367-70.
13. Salehpour S, Sene AA, Saharkhiz N, Sohrabi MR, Moghimian F. N-Acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. J Obstet Gynaecol Res. 2012 Sep; 38(9):1182-6. doi: 10.1111/j.1447-0756.2012.01844.x
14. Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol Scand. 2007; 86(2):218-22.
15. Abu Hashim H, Anwar K, El-Fatah RA. N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial. J Womens Health (Larchmt). 2010 Nov; 19(11):2043-8. doi: 10.1089/jwh.2009.1920
16. Elnashar A, Fahmy M, Mansour A, Ibrahim K. N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study. Fertil Steril. 2007 Aug; 88(2):406-9.
17. Oner G, Muderris II. Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011 Nov; 159(1):127-31. doi: 10.1016/j.ejogrb.2011.07.005
18. Fulghesu AM, Ciampelli M, Muzj G, Belosi C, Selvaggi L, Ayala GF, Lanzone A. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun; 77(6):1128-35.
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Dabbaghi Ghale T, Mohebbi F, Movahed F, Pakniat H, Yazdi Z. Effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome. J Gorgan Univ Med Sci 2016; 18 (3) :1-6
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Volume 18, Issue 3 (10-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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