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:: Volume 18, Issue 2 (6-2016) ::
J Gorgan Univ Med Sci 2016, 18(2): 54-60 Back to browse issues page
Effect of long term administration of tamoxifen on memory in male rat
Asle-Rousta M *
Academic Instructor, Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran , mrousta@iauz.ac.ir
Abstract:   (11702 Views)

Background and Objective: Tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues. This study was done to evaluate the effect of chronic administration of tamoxifen on spatial memory and passive avoidance task in adult male Wistar rats.

Methods: In this experimental study, 48 adult male Wistar rats were randomly divided into control, sham and tamoxifen groups. Animals in sham and tamoxifen groups were received tamoxifen solution and tamoxifen (400mg/kg/day) orally for 35 consecutive days. At the end of treatment, spatial learning and memory of animals was assessed using the Morris water maze task and passive avoidance memory was examined using the shuttle box.

Results: The time spent and distance moved to reach the platform, significantly increased in tamoxifen group compared to controls (P<0.05). In addition, the time spent and distance moved in the target quadrant (in the probe test) significantly reduced in tamoxifen group in compared to controls (P<0.05). In passive avoidance task, tamoxifen significantly decreased the time of the entrance to the dark room compared to control animals (P<0.05).

Conclusion: Long-term administration of tamoxifen impairs spatial learning and memory and passive avoidance memory in rats.
Keywords: Tamoxifen, Spatial learning, Spatial memory, Avoidance memory, Rat
Full-Text [PDF 345 kb] [English Abstract]   (14420 Downloads) |   |   Abstract (HTML)  (587 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Asle-Rousta M. Effect of long term administration of tamoxifen on memory in male rat. J Gorgan Univ Med Sci 2016; 18 (2) :54-60
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Volume 18, Issue 2 (6-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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