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:: Volume 18, Issue 2 (6-2016) ::
J Gorgan Univ Med Sci 2016, 18(2): 41-45 Back to browse issues page
Effect of hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice
Kavyanifard S1 , Heidarieh N * 2, Jamalo F3 , Alinejad G4 , Alinejad M5 , Mohammad Eini A6
1- M.Sc in Physiology, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
2- Assistant Professor, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran , nheidarieh@yahoo.com
3- Assistant Professor, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
4- Veterinary Student, Member of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
5- Master of Poultry, a member of the Technology poultry, Qom, Iran
6- M.Sc in Histology, Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract:   (13340 Views)

Background and Objective: Epilepsy is a common neurological disorder. Plantago major (P.major) is used in traditional medicine due to flovonoids and vitamic C and antioxidant properties. This study was done to evaluate the hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice.

Methods: In this experimental study, 50 NMRI male mice randomly allocated into control and four experimental groups. Seizures in animals induced by 60 mg/kg/bw of pentilentetrazol (PTZ), interperitoneally. Animals in experimental groups were received 5, 10, 25 and 50 mg/kg/bw of hydro alcoholic extract of Plantago major L. 30 min before each PTZ injection. The animals in control group were received saline, interperitoneally. After treatment, the behavior of animals during 20 minutes and mortality rate were recorded.

Results: Seizure threshold of animals significantly increased in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05). Mortality rate of animals significantly reduced in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05).

Conclusion: The hydro-alcoholic extract of Plantago major L. reduces seizure threshold in pentilentetrazol-induced seizures mice.

Keywords: Plantago major L, Pentylentetrazole, Seizure threshold, Mouse
Full-Text [PDF 186 kb] [English Abstract]   (14782 Downloads) |   |   Abstract (HTML)  (913 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
References
1. Mahmudi M, Heidary M, Zohour AR. [Effect of Ruta Graveolens hydro-alcoholic extract on Pentylenetetrazole-induced seizure in male mice]. J Kerman Univ Med Sci. 2001;8(2): 88-94. [Article in Persian]
2. Arzi A. [Search for fresh perspectives in pharmacotherapy of epilepsy]. Ahvaz: Publication of the Ministry of Health and Medical Education Ahvaz. 2009; pp: 16-25. [Persian]
3. Nourpanah M. [Evaluation of morphine dependence on the seizure threshold of PTZ, Picrotoxin, caffeine and N-methyl-D-aspartate acid in rats]. Thesis for M.Sc degree in Nusing. 2010. Qom Branch, Islamic Azad University. [Persian]
4. Dhir A, Naidu PS, Kulkarni SK. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec; 30(8): 1478-85.
5. Ma Y, Yun SR, Nam SY, Kim YB, Hong JT, Kim Y, et al. Protective effects of sanjoinine a against N-methyl-D-aspartate-induced seizure. Biol Pharm Bull. 2008 Sep; 31(9):1749-54.
6. Knapp DJ, Crews FT. Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal. Alcohol Clin Exp Res. 1999 Apr; 23(4): 633-43.
7. Feyz Sanni N, Vaghari H, Jafarizadeh H. [Medicinal properties of plantain]. Congress in Bojnourd, North Khorasan University of Medical Sciences. 2012. [Persian]
8. Mirzaei A, Mohammadi J, Mirzaei N, Mirzaei M. [The antioxidant capacities and total phenolic contents of some Medicinal Plants in Iran]. J Fasa Univ Med Sci. 2011; 1(3): 160-67. [Article in Persian]
9. Nejati V, Khaneshi F. [Effect of hydro-alcoholic extract of Plantago major leaf on serum level of insulin, glucose, and histology of pancreas and kidney in Streptozotocin-induced diabetic rats]. Qom Univ Med Sci J. 2013; 7(5): 14-20. [Article in Persian]
10. Ong ES. Extraction methods and chemical standardization of botanicals and herbal preparations. J Chromatogr B. 2004 Dec; 812(1-2): 23-33.
11. Atta AH, Abo EL-Sooud K. The antinociceptive effect of some Egyptian medicinal plant extracts. J Ethnopharmacol. 2004 Dec; 95(2-3):235-8.
12. Mamessier E, Broussais-Guillaumot F, Chetaille B, Bouabdallah R, Xerri L, Jaffe ES, et al. Nature and importance of follicular lymphoma precursors. Haematologica. 2014 May; 99(5): 802-10. doi:10.3324/haematol.2013.085548
13. Pourgholami MH, Kamalinejad M, Javadi M, Majzoob S, Sayyah M. Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. J Ethnopharmacol. 1999 Feb; 64(2): 167-71.
14. van Luijtelaar EL, Ates N, Coenen AM. Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats. Epilepsia. 1995 Jan; 36(1): 86-92.
15. Zapata-Sudo G, Mendes TC, Kartnaller MA, Fortes TO, Freitas NF, Kaplan MA, et al. Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice. J Ethnopharmacol. 2010 Jul; 130(1): 9-12. doi:10.1016/j.jep.2010.03.013
16. Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, et al. Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol. 2007 Dec; 74(11): 1619-27.
17. Pellmar TC, Wilson WA. Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. Science. 1977 Aug; 197 (4306): 912-4.
18. Yang HN, Kim DJ, Kim YM, Kim BH, Sohn KM, Choi MJ, et al. Aloe-induced Toxic Hepatitis. J Korean Med Sci. 2010 Mar; 25(3): 492-95. doi:10.3346/jkms.2010.25.3.492
19. Takemiya T, Matsumura K, Yamagata K. Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int. 2007 Jul-Sep; 51(2-4):112-20.
20. Shad MA, Nawaz H, Rehman T, Ikram N. Determination of some biochemicals phytochemicals and antioxidant properties of different parts of cichorium intybus L.: a comparative study. J Anim Plant Sci. 2013; 23(4): 1060-66.
21. Kułak W, Sobaniec W, Wojtal K, Czuczwar SJ. Calcium modulation in epilepsy. Pol J Pharmacol. 2004 Jan-Feb; 56(1): 29-41.
22. Heidary MR, Razban F. [Effects of methanol extract of valerian (Valeriana officinalis) on seizure induced by picrotoxin in mice]. J Kerman Univ Med Sci. 2004; 11(2): 100-108. [Article in Persian]
23. Keihanian, F, Rostampour Vajari M, Saeidynia, A, Elmieh A. [Effect of Ruta Graveolens hydro-alcoholic extract on Pentylenetetrazole-induced Seizure in male mice]. J Babol Uni Med Sci. 2012; 14(4): 30-36. [Article in Persian]
24. Oliveira MS, Furian AF, Royes LF, Fighera MR, Fiorenza NG, Castelli M, et al. Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. Epilepsy Res. 2008 Mar; 79(1):14-21. doi:10.1016/j.eplepsyres.2007.12.008
25. Martínez-González J, Rodríguez-Rodríguez R, González-Díez M, Rodríguez C, Herrera MD, Ruiz-Gutierrez V, et al. Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism. J Nutr. 2008 Mar; 138(3):443-8.
26. Garavand S, Keramati K, Zendehdel M, Jadidoleslami M, Garavand S. Effect of intracerebroventricular injection of flunixin meglumine on PTZ-induced seizures in male rats. Physiol Pharmacol. 2010; 14(1): 34-40.
27. Rakhade SN, Loeb JA. Focal reduction of neuronal glutamate transporters in human neocortical epilepsy. Epilepsia. 2008 Feb; 49(2): 226-36.
28. de Araújo PF, Coelho-de-Souza AN, Morais SM, Ferreira SC, Leal-Cardoso JH. Antinociceptive effects of the essential oil of Alpinia zerumbet on mice. Phytomedicine. 2005 Jun; 12(6-7): 482-6.
29. Xia WL, Chipman JG, Robertson DL, Erikson RL, Simmous DL. Expression of a mitogen-responsive geneencoding prostaglandin synthease in regulated by MRNA splicing. Proc Natl Acad Sci U S A. 1991 Apr; 88(7): 2692-96.
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Kavyanifard S, Heidarieh N, Jamalo F, Alinejad G, Alinejad M, Mohammad Eini A. Effect of hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice. J Gorgan Univ Med Sci 2016; 18 (2) :41-45
URL: http://goums.ac.ir/journal/article-1-2760-en.html


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Volume 18, Issue 2 (6-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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