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:: Volume 18, Issue 2 (6-2016) ::
J Gorgan Univ Med Sci 2016, 18(2): 41-45 Back to browse issues page
Effect of hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice
Kavyanifard S1 , Heidarieh N * 2, Jamalo F3 , Alinejad G4 , Alinejad M5 , Mohammad Eini A6
1- M.Sc in Physiology, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
2- Assistant Professor, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran , nheidarieh@yahoo.com
3- Assistant Professor, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
4- Veterinary Student, Member of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
5- Master of Poultry, a member of the Technology poultry, Qom, Iran
6- M.Sc in Histology, Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract:   (11863 Views)

Background and Objective: Epilepsy is a common neurological disorder. Plantago major (P.major) is used in traditional medicine due to flovonoids and vitamic C and antioxidant properties. This study was done to evaluate the hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice.

Methods: In this experimental study, 50 NMRI male mice randomly allocated into control and four experimental groups. Seizures in animals induced by 60 mg/kg/bw of pentilentetrazol (PTZ), interperitoneally. Animals in experimental groups were received 5, 10, 25 and 50 mg/kg/bw of hydro alcoholic extract of Plantago major L. 30 min before each PTZ injection. The animals in control group were received saline, interperitoneally. After treatment, the behavior of animals during 20 minutes and mortality rate were recorded.

Results: Seizure threshold of animals significantly increased in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05). Mortality rate of animals significantly reduced in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls (P<0.05).

Conclusion: The hydro-alcoholic extract of Plantago major L. reduces seizure threshold in pentilentetrazol-induced seizures mice.

Keywords: Plantago major L, Pentylentetrazole, Seizure threshold, Mouse
Full-Text [PDF 186 kb] [English Abstract]   (11370 Downloads) |   |   Abstract (HTML)  (749 Views)  
Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Kavyanifard S, Heidarieh N, Jamalo F, Alinejad G, Alinejad M, Mohammad Eini A. Effect of hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice. J Gorgan Univ Med Sci 2016; 18 (2) :41-45
URL: http://goums.ac.ir/journal/article-1-2760-en.html


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Volume 18, Issue 2 (6-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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