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Genotoxic and cytotoxic effect of mirtazapine in human peripheral blood lymphocyte: in vitro study
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Norizadeh Tazehkand M *   1, Topaktas M2 , Hajipour O3 |
1- Ph.D Candidate in Biotechnology, Department of Biotechnology, Cukurova University, Adana, Turkey , mostafa_noorizadeh@yahoo.com
2- Professor, Department of Biotechnology, Cukurova University, Adana, Turkey
3- Ph.D Candidate in Molecular Biology, Department of Basic Sciences, Pamukkale University, Denizli, Turkey |
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Abstract: (13836 Views) |
| Background and Objective: Mirtazapine is a norepinephrine and serotonergic antidepressant that is used in the theraphy of major depressive disorders. This study was carried out to determine the genotoxic and cytotoxic effect of mirtazapine using chromosome aberration and mitotic index tests in human peripheral blood lymphocytes. Methods: In this descriptive -analytic study genotoxic and cytotoxic effect of mirtazapine at 24 and 48 hours treatment periods on four concentration (10, 25, 40, and 55µg/ml) was performed on peripheral blood lymphocyte of four subjects. Results: Mirtazapine significantly reduced the mitotic index in the all concentrations but it non-significantly increased the chromosome aberration at 24-hours and 48-hours treatment periods. Conclusion: Mirtazapine has cytotoxic effect but it has no genotoxic effect on human lymphocyte. |
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| Keywords: Mirtazapine, Cytotoxicity, Genotoxicity, Chromosome Aberration, Mitotic index, Lymphocyte |
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Full-Text [PDF 229 kb]
[English Abstract]
(19357 Downloads)
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Type of Study: Original Articles |
Subject:
Genetic
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