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:: Volume 17, Issue 2 (7-2015) ::
J Gorgan Univ Med Sci 2015, 17(2): 87-91 Back to browse issues page
Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility
Yousefi M1 , Salehi Z * 2, Mashayekhi F3 , Bahadori MH4
1- M.Sc student in Cell and Developmental Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
2- Professor, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran , geneticzs@yahoo.co.uk
3- Professor, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
4- Associate Professor, Cellular and Molecular Research Center, Faculty of Medical Sciences, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (7885 Views)
Background and Objective: Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and affects about 5.0-7.0% of the general male population. Human apurinic/apyrimidinic endonuclease (ApE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. ApE1 SNP T>G found in exon 5 led to substitution of Asp>Glu at codon 148. This study was done to evaluate the association of ApE1 Asp148Glu polymorphism and the risk of idiopathic male infertility. Methods: In this case-control study, blood samples were collected from 90 patients diagnosed with idiopathic male infertility and 90 healthy men, genotyped by Allele-Specific PCR (AS-PCR) method by using specific primers that were designed and the association between genotype and allele frequencies in cases and controls were estimated. Results: There was no significant association between ApE1 gene polymorphism at codon 148 in case and control groups. Conclusion: No significant association was found between the Asp148Glu polymorphism and idiopathic male infertility.
Keywords: Infertility, Male, Polymorphism, ApE1 gene
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Type of Study: Original Articles | Subject: Genetic
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Yousefi M, Salehi Z, Mashayekhi F, Bahadori MH. Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility. J Gorgan Univ Med Sci 2015; 17 (2) :87-91
URL: http://goums.ac.ir/journal/article-1-2378-en.html


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Volume 17, Issue 2 (7-2015) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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