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:: Volume 4, Issue 2 (Autumn & Winter 2002) ::
J Gorgan Univ Med Sci 2002, 4(2): 25-29 Back to browse issues page
Comparison of the Ornithine Carbamyltransferase with Aspartate Aminotransferase and Alanine Aminotransferase in patients with liver diseases
HR.Joshaghani * 1, M.Jalali , AS.Lotfi , E.Javadi , AR.Bandegi
Abstract:   (25130 Views)
Liver is an important organ with major role in carbohydrates, proteins and lipids metabolism. In addition, secretion and excretion of toxic materials occur in this organ. Exposure to a variety of infectious agents such as parasitic, viral, bacterial or toxic materials may lead to liver damage. Today, one of the best way for investigation and diagnosis of liver damage is measurement of some liver enzyme such as Alanine Aminotransferase (GPT or ALT), Aspartate Aminotransferase (GOT or AST). Since, these enzymes exist in other tissues, measurement of other specific enzyme is required. In this study activity of Ornithine Carbamyltransferase (OCT), the second enzyme in urea cycle, in 56 patients with liver problem (Cirrhosis and viral hepatitis) was determined. SGPT, SGOT, Alb, Bil, ?GT and ALP tests were performed. To assess the health and unhealthy liver in both control and sample groups. Our data shows a correlation between activity of OCT with SGOT (R=0.782, P<0.001) and with SGPT (R=0.857, P<0.001). Since OCT enzyme is specific for liver, further investigation of activity of this enzyme in assessment of other liver problems is required.
Keywords: Liver disease, Ornithine carbamyltransferase, Alanine aminotransferase, Aspartate aminotransferase
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Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Department of Medical Laboratory sciences, College of allied medicine, Golestan University of Medical Sciences


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HR.Joshaghani, M.Jalali, AS.Lotfi, E.Javadi, AR.Bandegi. Comparison of the Ornithine Carbamyltransferase with Aspartate Aminotransferase and Alanine Aminotransferase in patients with liver diseases . J Gorgan Univ Med Sci 2002; 4 (2) :25-29
URL: http://goums.ac.ir/journal/article-1-234-en.html


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Volume 4, Issue 2 (Autumn & Winter 2002) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)