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Effect of alcoholic extract of Ginger during fetal life and breastfeeding on serum level of testosterone, LH, FSH and spermatogenic cells line in male mature offspring rats
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Hosseini SE *   1, Jahandidea A2 , Mehrabani D3 |
1- Associate Professor, Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran , ebrahim.hossini@yahoo.com
2- M.Sc in Animal Physiology, Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
3- Assistant Professor, Department of Pathology, Director of Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: (14018 Views) |
| Background and Objective: Ginger as a medicinal herb is used as a food flavoring and thraphy of many diseases including infertility and male sexual disabilities. This study was carried out to evaluate the effect of alcoholic extract of Ginger during fetal life and breastfeeding on serum level of testosterone, LH, FSH and spermatogenic cell lines in male mature offspring rats. Methods: In this experimental study, 72 female adult mice were randomly allocated into the 9 groups, including: control group (no treatment), sham groups including neonatal and perinatal groups which were received normal salin (0.5 ml daily) and 6 interventional groups. Animals in interventional groups were received doses of 50, 100 and 200 mg/kg/bw of alcoholic extract of Ginger, during neonatal and perinatal period, orally. After puberty eight male rats from each group were sacrified. Serum level of testosterone, LH, FSH were measeared and then by isolating testes, the cell numbers of leydig, sertoli, spermatogonia, spermatocyte and spermatid were counted. Results: The extract of Ginger dose-dependently significantly increased the level of testosterone (P<0.05) and the number of spermatogenic cells in compared to controls (P<0.05). The dosage of 100 and 200 mg/kg/bw of alcoholic extract of Ginger significantly reduced the FSH and LH in compared to controls (P<0.05) Conclusion: The oral consumption of Ginger during pregnancy and lactation dose-dependently increase the level of testosterone and the number of spermatogenic cells. |
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| Keywords: Ginger, Testosterone, Luteinizing Hormone, Follicle stimulating hormone, Spermatogenic cell line, Rat |
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Full-Text [PDF 931 kb]
[English Abstract]
(14135 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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