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Effect of Amphotericin B and Fluconazole on hospital wards fungi
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Nowrozi H *   1, Nowrozi H2 , Kazemi A3 , Khaji L4 |
1- Assistant Professor, Department of Laboratory Science, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , nowrozi.h@iums.ac.ir
2- Pharmacologist
3- Assistant Professor, Department of Nursing, College of Nursing and Midwifery, Varamin (Pishva) Branch, Islamic Azad University, Varamin , Iran
4- Veterinary Medicine, Department of Basic Sciences, School of Veterinary Medicine, Tehran University of Medical Sciences, Tehran, Iran |
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Abstract: (10754 Views) |
| Background and Objective: Nosocomial fungal infections have considerably increased due to incrasing of immunocompromised diseases. This study was done to evaluate the antifungal activity of Amphotericin B and Fluconazole on hospital wards fungi. Methods: In this descriptive - analytic study, 33 fungal samples isolated from Imam Khomini hospital in Tehran, Iran during 2013. Samples were identified using slide culture method. Serial dilution of drugs and fungal suspensions were supplied from 0.25-128 µg/ml and range 0.5–5×105 cfu/ml, respectively. Minimum inhibitory concentration (MIC) was determined in accordance with NCCLS M38-p guideline. Results: The most frequent isolated fungus was Aspergillus spp. with 39.4% while the low frequent were Alternaria Spp. and Circinella with similar frequency (3%). MIC range for Fluconazole and Amphotericin B were 64-128 µg/ml and 16-64 µg/ml, respectively. Amphotericin B showed a MIC significant reduction in comparision with Fluconazole (P<0.05). Conclusion: Hospital wards fungi were resistant to Amphotericin B and Fluconazole. |
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| Keywords: Fungus, Amphotericin B, Fluconazole, MIC, Hospital |
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Full-Text [PDF 263 kb]
[English Abstract]
(16205 Downloads)
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Type of Study: Short Communication |
Subject:
Medical Mycology
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