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:: Volume 16, Issue 4 (12-2014) ::
J Gorgan Univ Med Sci 2014, 16(4): 74-79 Back to browse issues page
Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients
Heidari Kh1 , Azarhoush R * 2, Forghanifar M3
1- MS.c in Microbiology, Islamic Azad Univercity, Danghan Branch, Damghan, Iran
2- Associate Professor, Department of Pathology, Golestan Univercity of Medical Sciences, Gorgan , Iran , raminazarhoush@yahoo.com
3- Assistant Professor, Ph.D in Genetics Molecular, Islamic Azad Univercity, Danghan Branch, Damghan, Iran
Abstract:   (12489 Views)
Background and Objective: Helicobacter pylori is the main gastric pathogen in human. BabA2 and Hsp genotypes are essential for enormous clinical outcomes in gastreodeoneal and dyspepsia. This study was done to determine the assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients. Method: This descriptive-analytic study was carried out on 80 digestive disorders patients in 5th hospital, Gorgan, northern Iran. Stomach specimen biopsy was taken by a gastroenterologist. Urease test, histopathologic assessment and DNA extraction were performed. The frequency of babA2 and hsp geno-types was determined using poly merase chain reaction. Results: In 80 affected patients with H.pylori, 36, 18 and 26 patients were found to suffer from gastritis, stomach cancer and stomach ulcer, respectively. 51 specimens (63%) were positive babA2 genotype. 49 specimens (61%) were positive hsp genotype. No significant relationship was found between babA2 and hsp geno types with stomach diseases. Conclusion: In spite of positive babA2 and hsp genotype in isolated Helicobacter pylori speicments from digestive disorders patients, this finding was not correlated with type of digestive disorders.
Keywords: Helicobacter pylori, babA2 gene, Hsp gene, Gastric disease
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Type of Study: Original Articles | Subject: Microbiology
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Heidari Kh, Azarhoush R, Forghanifar M. Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients. J Gorgan Univ Med Sci 2014; 16 (4) :74-79
URL: http://goums.ac.ir/journal/article-1-2197-en.html


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Volume 16, Issue 4 (12-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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