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Relationship between serum cardiac troponin T and I with Left ventricular hypertrophy and systolic dysfunction in hemodialysis patients
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Sedighi O1   , Golshani S * 2, Nikzad F3 |
1- Assistant Professor, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2- Assistant Professor, Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran , dr_golshani@yahoo.com
3- Medical Student, Mazandaran University of Medical Sciences, Sari, Iran |
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Abstract: (9116 Views) |
| Background and Objective: Cardiovascular diseases are the most frequent cause of death among hemodialysis patients. Left ventricular hypertrophy and systolic dysfunction are potent predictors of cardiovascular morbidity and mortality in hemodialysis patients. Cardiac troponin T and I are the indices of myocardial cell damage. This study was done to determine the relationship between serum cardiac troponin T and I with left ventricular hypertrophy and systolic dysfunction in hemodialysis patients. Method: In this case-control study, 56 hemodialysis patients were divided into two groups according to echocardiographic findings. The first group included 35 patients with left ventricular hypertrophy as case group and 21 patients without left ventricular hypertrophy as controls. Serum level of cardiac troponin T and I were measured using electro chemiluminscence immune assay. Results: Serum level of cardiac troponin T and I was significantly higher in patients with left ventricular hypertrophy (0.99±0.12 ng/ml and 0.17±0.09 ng/ml, respectively) in comparison with controls (0.37±0.05 ng/ml and 0.13±0.09 ng/ml, respectively) (P<0.05). There was no correlation between serum cardiac troponin T and I level with left ventricular systolic dysfunction. Conclusion: Cardiac troponin I and T do not have any value for the diagnosis of left ventricular systolic dysfunction in hemodialysis patients. |
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| Keywords: Hemodialysis, Left ventricular hypertrophy, Left ventricular systolic dysfunction, Cardiac Troponin T, Cardiac Ttroponin I |
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Full-Text [PDF 259 kb]
[English Abstract]
(16981 Downloads)
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Type of Study: Original Articles |
Subject:
Cardiovascular
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