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:: Volume 16, Issue 4 (12-2014) ::
J Gorgan Univ Med Sci 2014, 16(4): 14-20 Back to browse issues page
Effect of hydro-ethanolic extract of Chamaemelum nobile on cell prolifration and apoptosis of rat hipocample neural stem cells in the oxitative stress condition
Abdanipour A * 1, Khatami SM2 , Tiraihi T3 , Satari MJ4
1- Assistant Professor, Department of Anatomy, Stem Cells Research Laboratory, Islamic Azad University, Ardabil Branch, Ardabil, Iran , abdani.anatomy@yahoo.com
2- M.Sc in Biology, Young Researchers and Elite Club, Islamic Azad University, Ardabil Branch, Ardabil, Iran
3- Professor, Shefa Neurosciences Research Center, Khatam Al-Anbia Hospital, Department of Pathology, Tehran, Iran
4- Medical Student, Young Researchers and Elite Club, Islamic Azad University, Ardabil Branch, Ardabil, Iran
Abstract:   (10102 Views)
Background and Objective: Neural stem cells can difrentiate to mature neural cells. Neural stem cells can migrate and repair the damage neural tissue. This study was done to determine the effect of hydro-ethanolic extract of Chamaemelum nobile on cell prolifration and apoptosis of rat hipocample neural stem cells in the oxitative stress condition. Methods: In this experimental study, neural stem cells were isolated from hippocampus of neonatal rat brain. Isolated neural stem cells were treated at 200, 400, 600, 800 and 1000 µg/ml of hydro-ethanolic extract of Chamaemelum nobile for 48h. Cells proliferation rate were evaluated by MTT assay. Anti-apoptotic property of hydro-ethanolic extract of Chamaemelum nobile evaluated using TUNEL assay method. Results: Proliferation of neural stem cells were significantly increased in Chamaemelum nobile extract group in comparision with control (P<0.05). The rate of apoptotic cells were significantly reduced in Chamaemelum nobile extract group compared to control (P<0.05). Conclusion: The hydrethanolic extract of Chamaemelum nobile increases proliferation rate and reduces apoptosis of neural stem cells in the oxitative stress condition.
Keywords: Neural stem cell, Chamaemelum nobile, Cell proliferation, Apoptosis
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Type of Study: Original Articles | Subject: Stem Cells
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Abdanipour A, Khatami SM, Tiraihi T, Satari MJ. Effect of hydro-ethanolic extract of Chamaemelum nobile on cell prolifration and apoptosis of rat hipocample neural stem cells in the oxitative stress condition. J Gorgan Univ Med Sci 2014; 16 (4) :14-20
URL: http://goums.ac.ir/journal/article-1-2189-en.html
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Volume 16, Issue 4 (12-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)