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Effect of quercetin on learning and memory in STZ-induced diabetic rat
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Nasri S *   1, Rahimi M2 , Mozafari M2 |
1- Associate Professor, Department of Biology, Payamenoor University, Tehran, Iran , s_nasri1@pnu.ac.ir
2- M.Sc in Biology, Department of Biology, Payamenoor University, Tehran, Iran |
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Abstract: (13643 Views) |
| Background and Objective: Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZ-induced diabetic rats was investigated. Methods: In this experimental study, 40 male Wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin - treated diabetic (10 and 20 mg/kg/bw, intraperitoneally) for 14 days. Induction of diabetes was performed using 60 mg/kg/bw of streptozotosin, interapritonally. Passive avoidance and Y-maze tests were used for the evaluation of learning and memory. Results: In passive avoidance learning, there was no significant difference in initial latency between diabetic and treated - diabetic groups. The mean of step latency in control group (383.57±19.26) significantly reduced to 128.86±10.38 in diabetic group (P<0.05). The mean of step latency in the treated diabetic group significantly increased in compare to the diabetic group (P<0.05). Step latency in quercetin - treated diabetic (10 mg/kg/bw) and (20 mg/kg/bw) groups increased to 316.67±23.76 and 397.50±31.21, respectively. The alternative percentage in diabetic group was significantly lower than control group (P<0.05), but in quercetin -treated diabetic groups it was higher than the diabetic group (P<0.05). Conclusion: Administration of quercetin for 14 days enhances the capability of the memory storage, recall and improves short-term spatial memory in STZ-induced diabetic rats. |
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| Keywords: Diabetes, Quercetin, Learning, Memory, Rat |
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Full-Text [PDF 391 kb]
[English Abstract]
(15421 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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