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Anti ulcerogenic activity of Bunium percicum Boiss. essential oil in induced ulcer models in Wistar rats
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Jalilzadeh-Amin G *   1, Yousefi AR2 , Abdollahi-Pirbazari M3 |
1- AssistantProfessor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , g.jalilzadeh@urmia.ac.ir
2- Urmia University, Veterinary Surgery Resident, Urmia, Iran
3- Tehran University, Small Animal Internal Medicine Resident, Tehran, Iran |
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Abstract: (20734 Views) |
| Background and Objective: Bunium percicum is often used in Iranian traditional medicine for the treatment of gastrointestinal disorders particularly gastric ulcer.This study was done to evaluate the antiulcerogenic effect of Bunium percicum Boiss.essential oil against indomethacin and ethanol – induced ulcer models in Wistar rats. Methods: This experimental study was carried out on rats weighing 200-220 g in veterinary college of Urmia University, Iran. LD50 was calculated based on Lorke’s method. To evaluate the short term oral toxicity, animals were allocated into four group of six each. In groups 1-3 animals were received orally 250, 125, 80 mg/kg/bw of Bunium percicum Boiss.essential oil, respectively. Controls were received Tween 80 (2%) orally for 14 consecutive days and monitored daily. Bunium percicum Boiss. essential oil was administered orally at doses of 20, 40 and 80 mg/kg/bw and cimetedin (10 mg/kg/bw) and omopirazol (30 mg/kg/bw) in indomethacin and ethanol–induced ulcer models. Results: The LD50 was 375 mg/kg/bw. Daily single oral doses of Bunium percicum Boiss.essential oil tolerated behaviorally after 14 days without any alterations in body and organs weight, food, water consumption and serum total protein, alanine and aspartate aminotransferase activity. The preventive index in doses of 40 and 80 mg/kg/BW of Bunium percicum Boiss.essential oil was 37.98% and 59.21%, respectively in the indomethacin -induced ulcer model (P<0.05). In the model of ethanol -induced ulcer, the preventive index in doses of 40 and 80 mg/kg of Bunium percicum Boiss. essential oil was 12.40% and 22.05%, respectively (P<0.05). Conclusion: The essential oil of Bunium percicum Boiss is completely ‘‘safe’’ and at the doses of 40 and 80mg/kg/bw significantly prevent gastric ulcers in animal model. |
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| Keywords: Bunium percicum Boiss., Gastric ulcer, Indomethacin, Ethanol |
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Full-Text [PDF 303 kb]
[English Abstract]
(22451 Downloads)
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Type of Study: Original Articles |
Subject:
Physiology - Pharmacology
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