[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Instruction to Authors::
Contact Us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 6, Issue 2 (Autumn & Winter 2004) ::
J Gorgan Univ Med Sci 2004, 6(2): 26-31 Back to browse issues page
Tuberculin reaction in 4.5 months babies and 7 years old children, vaccinated with BCG at birth
E.Ghaemei (Ph.D) * 1, MA.Vakili (M.Sc) , B.Khodabakhshi (M.D) , S.Bakhshandehnosrat (M.D) , S.Aghapour (M.D) , M.Naeimei-Tabiei (M.D) , A.Tabrraei (M.Sc) , SA.Hosenei (M.Sc)
Abstract:   (22584 Views)
Background & Objective: Approximately one-third of the world’s population is infected with Mycobacterium Tuberculosis (TB), which is a indicator of high distribution of these bacteria in our environment. The only vaccine currently available against TB is the attenuated Mycobacterium Bovis strain bacillus Calmette-Guerin (BCG), which used regularly for many years to prevent the Tuberculosis in Iran and many part of the world. The efficiency of this vaccine varies in different populations, and is a matter for discussion. On this basis, the present study has been set up to determine the level of Tuberculin reaction in 4.5 months and in 7 years old children that receive BCG vaccine at birth time, in Golestan province. Materials & Methods: 2700, 4.5 month infant and 2400, 7 years old children in Golestan province were chosen by cluster sampling after the proper permission from the parents, public health centers and educational authorities were taken. The presence of the BCG scar were assessed, and 0.1 ml of 5 tu Tuberculin were injected subcutaneously. The induration was measured 48-72 h after Tuberculin injection. The results were determined as present and compare with T-test. Results: In these study 2559 infants and 2193 child were taken part in the final evaluation. The BCG scar were present in 97.9% of infants and 87.8% of 7 years children, this difference was meaningful. The average induration in 4.5 months babies were 2.29 mm, and in 7 years child was 0.66 mm, this difference was significant (P<0.05). More than 44.7% of babies and 82% of 7 years children didn’t show any reaction after PPD test, this difference was also significant (P<0.05). Conclusion: The level of positive Tuberculin reaction in infants of this province in spite of vaccination was very low, and this level was reduced after 7 years time, this indicate that BCG vaccination at birth did not have any major role in positive Tuberculin reaction. Our results also indicate that the presence of scar can be a good indicator for previous vaccination. In regard to the negative Tuberculin reaction in majority of babies, it is suggested to evaluate the efficacy of BCG vaccine in preventing the TB disease itself, by other method such as studying the TB incidence among children in long term or by determination of cytokines level after Tuberculin injection.
Keywords: Tuberculin reaction, BCG vaccine, Scar, Child
Full-Text [PDF 182 kb]   (16014 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Department of Microbiology, Gorgan University of Medical Sciences. eghaemi@yahoo.com

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

E.Ghaemei (Ph.D), MA.Vakili (M.Sc), B.Khodabakhshi (M.D), S.Bakhshandehnosrat (M.D), S.Aghapour (M.D), M.Naeimei-Tabiei (M.D), et al . Tuberculin reaction in 4.5 months babies and 7 years old children, vaccinated with BCG at birth . J Gorgan Univ Med Sci 2004; 6 (2) :26-31
URL: http://goums.ac.ir/journal/article-1-198-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 2 (Autumn & Winter 2004) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4657