[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Instruction to Authors::
Peer-Review::
Contact Us::
Site Facilities::
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 6, Issue 2 (Autumn & Winter 2004) ::
J Gorgan Univ Med Sci 2004, 6(2): 15-21 Back to browse issues page
Evaluation of in vitro immune response of Opioid dependent individuals by measurement of Cytokines (Interferon-? and Interleukin-10) induced by cell stimulation compared with normal individuals
M.Mahmoodi (Ph.D) * 1, A.Azarang (M.D) , S.Rajabalian (M.Sc) , A.Zohoor (PhD)
Abstract:   (15851 Views)
Background & Objective: Few studies concerning the effects of Opioid drugs on the function of immune system have been conducted and conflicting results have been reported. This study evaluates the in-vitro immune responses of drug abusers and investigates the pattern of production of IFN-? and IL-10, which represents the subsets of CD4+T-helper cells. Materials & Methods: Blood samples were taken from healthy drug addicted volunteers. Blood samples were also taken from healthy individuals with no history of drug abuse as control. Cell culture was performed in whole blood culture assay. Diluted blood samples were stimulated with phytohemagglutinin (PHA) and lipopolysaccharide (LPS) and the supernatants were collected to measure the Cytokine production. Results: The results demonstrated that a significant decrease in IFN-? production and increase in IL-10 production in Heroin addicts, whereas the production of these Cytokines in Opium addicts was not significant different from those in control group. Conclusion: The results indicated a significant decrease in mitogenic responsiveness of T-cells in Heroin addicts relative to control group, whereas mitogenic responsiveness of T-cells in Opium addicts was not significantly different from control group.
Keywords: Opioids, T-cell, Interferon-gamma, Interleukin-10
Full-Text [PDF 290 kb]   (19319 Downloads)    
Type of Study: Original Articles | Subject: General
* Corresponding Author Address: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman. majid_mahmoodi@yahoo.com


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

M.Mahmoodi (Ph.D), A.Azarang (M.D), S.Rajabalian (M.Sc), A.Zohoor (PhD). Evaluation of in vitro immune response of Opioid dependent individuals by measurement of Cytokines (Interferon-? and Interleukin-10) induced by cell stimulation compared with normal individuals . J Gorgan Univ Med Sci 2004; 6 (2) :15-21
URL: http://goums.ac.ir/journal/article-1-196-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 2 (Autumn & Winter 2004) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4657