[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Aims and Scope
Content Coverage
Conflict of Interest
Publication Ethics
Editorial Board::
Executive Members::
Instruction to Authors::
Peer Review::
Articles Archive::
Current Issue
All Issues
Indexing Databases::
Contact Us::
Contact Us
Contact Form
Site Facilities::
Search contents
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 15, Issue 4 (12-2013) ::
J Gorgan Univ Med Sci 2013, 15(4): 66-71 Back to browse issues page
Drug susceptibility of Aspergillus flavus and A.fumigatus to Itraconazole and Amphotericin B
Kazemi A * 1, Nowrozi H2 , Teshfam M3 , Teimorian Sh4
1- Assistant Professor, Department of Pharmacology, Islamic Azad University, Science and Research Branch, Tehran, Iran , dr_ali_kazemi@yahoo.com
2- Assistant Professor, Department of Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
3- Associate Professor, Department of Physiology, Islamic Azad University, Science and Research branch, Tehran, Iran
4- Assistant Professor, Department of Genetics, Faculty of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (15237 Views)
Background and Objective: Aspergillosis is the most current causative agent of exogenous fungal nosocomial infection. This study was done to evaluate the drug susceptibility of Aspergillus flavus and A.fumigatus to itraconazole and amphotericin B. Materials and Methods: This Laboratory study was done on 25 Aspergillus fumigatus and 25 Aspergillus flavus species isolated from transplant's patients. Drug susceptibility test was done according to NCCLS M38-P document. Fungal suspensions of mentioned fungi were supplied with ranges 0.5–5×104 by spectrophotometer at 530 nm. Serial dilutions of drugs were supplied from 0.03125 to 16 µg/ml and MICs determined following 48h incubation at 35°C. Results: Obtained MICs ranges for Aspergillus fumigatus and Aspergillus flavus were 1-4 µg/ml and 0.5–4 µg/ml for itraconazole, respectively while MICs ranges against Aspergillus fumigatus and Aspergillus flavus were 0.5-2 µg/ml and 0.25-2 µg/ml for amphotericin B, respectively. Amphotericin B MICs were significantly lower than itraconazole (P<0.05). Conclusion: Aspergillus flavus and A.fumigatus were susceptible to amphotericin B and itraconazole.
Keywords: Aspergillus flavus, Aspergillus fumigatus, Drug susceptibility, Amphotericin B, Itraconazole
Full-Text [PDF 266 kb] [English Abstract]   (18466 Downloads)    
Type of Study: Original Articles | Subject: Medical Mycology
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Kazemi A, Nowrozi H, Teshfam M, Teimorian Sh. Drug susceptibility of Aspergillus flavus and A.fumigatus to Itraconazole and Amphotericin B. J Gorgan Univ Med Sci 2013; 15 (4) :66-71
URL: http://goums.ac.ir/journal/article-1-1878-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 15, Issue 4 (12-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4660
Creative Commons License
This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)