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Incidence of neural tube defects and its risk factors in Yasuj, Iran (2000-10)
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Roozitalab M1   , Mohammadi B2 , Ebrahimi S3 , Pourmahmoudi A * 4, Malekzadeh JM5 , Zandi Ghasghaie K1 , Mardani Hamoleh M6 |
1- Academic Instructor, Department of Operation Room, College of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Nurse, Department of Nursing, Imam Sajad Hospital, Yasuj University of Medical Science, Yasuj, Iran
3- Assistant Professor, Department of Pediatric, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- PhD Candidate in Nutrition, Academic Instructor, Department of Nutrition, Faculty of Health, Yasuj University of Medical Sciences, Yasuj, Iran , pourmahmoudi@gmail.com
5- Assistant Professor, Department of Nutrition, Faculty of Health, Yasuj University of Medical Sciences, Yasuj, Iran
6- PhD Candidate in Nursing, Tehran University of Medical Sciences, Tehran, Iran |
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Abstract: (12744 Views) |
| Background and Objective: The incidence of neural tube defects (NTDs) is varied according to race, geographical situation and other predisposing factors. This study was carried out to determine the incidence rate of NTDs and its risk factors in Yasuj, Iran. Materials and Methods: This case - control study was done on live newborns in Imam Sajad hospital, Yasuj, Iran during 2000-10. 78 neonates with NTDs out of 36755 live newborns were considered as cases. The control group was also consisting of the same number of healthy neonates who born at the same period and in the same hospital. Data were collected by a check-list and analyzed using SPSS-19, Chi-Square, Logistic regression and odd’s ratio. Results: The incidence rate of NTDs was 2.12 per 1000 live births. Anencephaly and Spina Bifida was detected in 59 (75.6%) and 19 (24.3%) of affected newborns, respectively. The ratio of females to males was 1.5 times. 53.85% of mothers with affected newborns were grouped in 27-36 years age range. The mean number of pregnancies and abortion between two groups of mothers had no statistical significant differences. There is no significant relation between the mothers occupation and the incidence of NTDs. 10 (12.8%) of mothers from case group and 7 (8.97%) of mothers from control group have used tobacco. 52 (66.7%) of mothers of case group and 30 (38.5%) of controls did not consumed folic acid. The relation between non-user folic acid during pregnancy with NTDs was significant (95% CI: 1.4-6.15, OR=2.93, P<0.001). Conclusion: This study showed relatively high incidence of NTDs in Yasuj. Non-consuming folic acid increased the risk of NTD by 2.93 times. |
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| Keywords: Neural tube defect, Folic acid, Abortion, Incidence |
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Full-Text [PDF 334 kb]
[English Abstract]
(12251 Downloads)
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Type of Study: Original Articles |
Subject:
Pediatric
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Roozitalab M, Mohammadi B, Ebrahimi S, Pourmahmoudi A, Malekzadeh JM, Zandi Ghasghaie K et al . Incidence of neural tube defects and its risk factors in Yasuj, Iran (2000-10). J Gorgan Univ Med Sci 2013; 15 (2) :82-89 URL: http://goums.ac.ir/journal/article-1-1772-en.html
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