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:: Volume 14, Issue 2 (6-2012) ::
J Gorgan Univ Med Sci 2012, 14(2): 65-69 Back to browse issues page
Comparison of antibody level in post hepatitis B vaccination in children with 12-15 and 21-24 months age
Ahmadi M (MD) * 1, Moosavi SM (MD)2 , Jahanfar F (MD)3
1- Assistant Professor, Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran , mshahmadi@yahoo.com
2- Assistant Professor, Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran
3- Pediatrician
Abstract:   (20165 Views)
Background and Objective: Infection with HBV is the most common chronic viral infection and mortality in children. Prevention of this infection with vaccination is vital. This study was done to compare the antibody level in post hepatitis B vaccination in children with 12-15 and 21-24 months age. Materials and Methods:This descriptive study was carreid out on 186 children with 12-15 (group I) and 21-24 (group II) months age who had not infected with hepatitis B infection in, Bandarabbas Iran during 2009. The parents were HbsAg negative, without immunodeficiency diseases and did not receive hepatitis vaccination, blood or blood products transfusion. Age, gender, birth weight, breast feeding duration and gestational age were recorded for each child. Hepatitis B antibody level was measured with ELISA method. Data were analyzed using SPSS-16 and student t-test. Results: Antibody level in group I (231 mIU/ml) was significantly higher than group II (142.9 mIU/ml) (P<0.05). There was not significant differences between males and females. Antibody level was not significantly corrolated with body weight, gestational age and breast feeding duration. Antibody level lower than 10 mIU/ml were observed in 4.34% of group I and 20.8% of group II. This differnce was significant (P<0.05). Conclusion: This study showed that the protective effect of vaccination reduced after six months of final dosage.
Keywords: Hepatitis B, Vaccine, Antibody, child
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Type of Study: Original Articles | Subject: Pediatric
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Ahmadi M (MD), Moosavi SM (MD), Jahanfar F (MD). Comparison of antibody level in post hepatitis B vaccination in children with 12-15 and 21-24 months age. J Gorgan Univ Med Sci 2012; 14 (2) :65-69
URL: http://goums.ac.ir/journal/article-1-1324-en.html


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Volume 14, Issue 2 (6-2012) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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