[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Instruction to Authors::
Peer-Review::
Contact Us::
Site Facilities::
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 14, Issue 2 (6-2012) ::
J Gorgan Univ Med Sci 2012, 14(2): 23-29 Back to browse issues page
Effect of Ginkgo biloba, Risperidone and Biperiden regimen in chronic schizophrenia
Nikfarjam M (MD)1 , Goodarzi I (MD)1 , Parsai Arshad SH (MD)2 , Parvin N (MSc) * 3, Safdari-Dehcheshmeh F (MSc)4
1- Assistant Professor, Department of Psychiatry, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2- General physician, Shahrekord University of Medical Sciences, Shahrekord, Iran
3- Academic Instructor, Psychiatric Nursing, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran , np285@yahoo.com
4- Academic Instructor, Department of Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract:   (29450 Views)
Background and Objective: Schizophrenia is a disorder characterized by a chronic recurrent course. Despite the availability of an ever-expanding range of typical and atypical antipsychotics, a substantial proportion of patients with schizophrenia show a partial or total lack of response to antipsychotic monotherapy. This study was done to evaluate the clinical effects of Ginkgo biloba as an adjunct to the Risperidone and Biperiden in the treatment of chronic schizophrenic patients. Materials and Methods: This randomized clinical trial study was carried out on 60 chronic schizophrenic patients in Sina hospital Shahrekord, Iran during 2009-10. Schizophrenia was diagnosed by DSM-IV-TR criteria. Subjects were randomly divided into intervention and control groups. Two groups were matched according to the age, sex, education, duration of illness. Patients in interventional group received Risperidone up to 6mg/day, Biperiden 4mg/day and Ginkgo biloba 240 mg/day for 12 weeks. The control group received Risperidone up to 6mg/day and Biperiden 4mg/day for 12 weeks. The scales for assessment of positive symptoms (SAPS) and assessment of negative symptoms (SANS) were recorded in prior, 6th and 12th weeks. Data analyzed by using SPSS-15 and student t-test. Results: The mean score of positive symptoms were 55.7±2.1 and 74.4±2.3 in interventional and control groups, respectively (P<0.05) after 12 weeks. The mean score of negative symptoms were 63±1.3 and 69.3±1.8 in interventional and controls, respectivley (P<0.05) after 12 weeks. Conclusion: This study suggested that the use of Ginkgo biloba as an adjunct to Respridone and Biperiden was more effective than Risperidone with Biperiden regimen improving psychological condition of chronic schizophrenic patients.
Keywords: Schizophrenia, Ginkgo biloba, Risperidone, Biperiden, Symptoms
Full-Text [PDF 274 kb] [English Abstract]   (18265 Downloads)    
Type of Study: Original Articles | Subject: Psychiatry
Send email to the article author


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nikfarjam M (MD), Goodarzi I (MD), Parsai Arshad SH (MD), Parvin N (MSc), Safdari-Dehcheshmeh F (MSc). Effect of Ginkgo biloba, Risperidone and Biperiden regimen in chronic schizophrenia. J Gorgan Univ Med Sci 2012; 14 (2) :23-29
URL: http://goums.ac.ir/journal/article-1-1317-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 14, Issue 2 (6-2012) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4657