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:: Volume 14, Issue 1 (3-2012) ::
J Gorgan Univ Med Sci 2012, 14(1): 106-112 Back to browse issues page
Prevalence of hemoglobinopathies in premarriage individuals referred to Babolsar, Iran (2006-09)
Valizadeh F (MD)1 , Mousavi A (BSc)2 , Hashemi-Soteh MB (PhD) * 3
1- Genetic Counselor, Babolsar Health Center, Deputy of Health, Mazandaran University of Medical Sciences, Babolsar, Iran
2- Manager of non-communicable disease, Babolsar Health Center, Deputy of Health, Mazandaran University of Medical Sciences, Babolsar, Iran
3- Assistant Professor, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , hashemisoteh@gmail.com
Abstract:   (17407 Views)

Background and Objective: According to world health organization statistics, at least 5.2% of world population is carrier for a main hemoglobin disorder. Previous reports showed that more than 10% of people are carrier for beta-thalassemia Northern Iran. This study was done to determine the prevalance of hemoglobinopathies in premarriage individuals referred to Babolsar, Iran.

Materials and Methods: This descriptive study was carried out on 8500 individuals  (4200 women and 4300 men) whome were attended the thalassemia counseling program in Babolsar, North of Iran during 2006-09. After performing the CBC test, for those MCV and MCH were less than 80 and 27 respectively, Hemoglobin A2 was evaluated. Subjects whome were volunteers for more comprehensive tests, basic and acidic electrophoresis and genetic tests were applied, subsequently.

Results: 1200 (14.11%) subjects had low hematological indexes. 474 (5.57%) subjects had high HbA2 and were classified as beta-thalassemia carriers and 726 (8.54%) had normal HbA2 level and were classified as alpha-thalassemia carriers. 6 (1.2%) subjects were identified with HbF level more than 10 and were identified as carriers for beta-gene cluster deletion carrier. Also, 16 (3.2%) individuals had HbE, 16 (3.2%) had HbS, 4 had HbD and 4 had HbH (0.33% in 1200 and 0.047% in 8500 subjects). Genetic study of 317 individuals for beta carriers and 145 subjects for alpha-carriers showed IVSII-1G>A (74.5%) in beta-globin and single gene deletion of 3.7 (47.5%) in alpha-globin genes were the most frequent mutations.

Conclusion: This study showed that carriers for alpha - thalassemia (8.5%) are more frequent compared with beta- thalassemia (5.57%). Also other hemoglobin variants included HbS, HbE, HbD or different beta-gene cluster deletions in the region are considerable and should be screened.

Keywords: Hemoglobin Variant, Alpha-thalassemia, Beta-thalassemia, Sickle cell anemia, Thalassemia prevalence, Beta gene deletion
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Type of Study: Original Articles | Subject: Genetic
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Valizadeh F (MD), Mousavi A (BSc), Hashemi-Soteh MB (PhD). Prevalence of hemoglobinopathies in premarriage individuals referred to Babolsar, Iran (2006-09). J Gorgan Univ Med Sci 2012; 14 (1) :106-112
URL: http://goums.ac.ir/journal/article-1-1250-en.html


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Volume 14, Issue 1 (3-2012) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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