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:: Volume 14, Issue 1 (3-2012) ::
J Gorgan Univ Med Sci 2012, 14(1): 100-105 Back to browse issues page
Prevalence of Glucose - 6 - phosphate dehydrogenase deficiency in neonates born in Tehran-Iran (2008-09)
Khalesy N (MD) * 1, Khosravi N (MD)2 , Haghighi M (MD)3
1- Assistant Professor, Department of Pediatric, Faculty of Medicine, Tehran University of Medical Sciences, Ali Asghar Hospital Tehran, Iran , nasrinkhalessi@yahoo.com
2- Associate Professor, Department of Pediatric, Faculty of Medicine, Tehran University of Medical Sciences, Ali Asghar Hospital Tehran, Iran
3- Pediatrician, Ali Asghar Hospital Tehran, Iran
Abstract:   (18818 Views)

Background and Objective: Regarding to probable high frequency of Glucose - 6 - phosphate dehydrogenase (G6PD) deficiency in Iran, screening of all neonates by cord blood is under consideration. This study was conducted to determine the prevalence of G6PD deficiency in newborns and the relation between gender, jaundice, hemolysis, anemia and the G6PD deficiency in neonated born in in Tehran, Iran.

Materials and Methods: In this descriptive study, cord blood of 450 neonates born in Akbarabady hospital in Tehran, Iran during 2008-09 were screened. Demographic information was recorded by questionnaires and the newborns were examined for detection of jaundice till discharge. G6PD level was determined by Fluorescent Spot Test (FST). G6PD deficient neonate were put under close observation for detection of jaundice. Enzyme activity was rechecked by spectrophotometry.

Results: Nine neonates out of 450 were G6PD deficient (8 boys and one girl). Prevalence of G6PD deficiency was 2% (3.3% for boys and 0.5% for girls). Six neonates of nine G6PD deficient neonates (66%) developed pathologic jaundice. Four neonates were managed by phototherapy and two by exchange transfusion.

Conclusion: This study showed that G6PD deficiency is more prevalate among male neonates, therefore, G6PD determination is recommended to prevent the possible neonatal jaundice.

Keywords: G6PD deficiency, Fluorescent spot test, Neonatal jaundice, Gender
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Type of Study: Original Articles | Subject: Pediatric
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Khalesy N (MD), Khosravi N (MD), Haghighi M (MD). Prevalence of Glucose - 6 - phosphate dehydrogenase deficiency in neonates born in Tehran-Iran (2008-09). J Gorgan Univ Med Sci 2012; 14 (1) :100-105
URL: http://goums.ac.ir/journal/article-1-1249-en.html


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Volume 14, Issue 1 (3-2012) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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