Jorjani Biomedicine Journal

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Background & Objective: High blood levels of IGF-1 in women before menopause, is a risk factor and P53 tumor suppressor gene is also one of the most common genes involved in breast cancer. Since some studies demonstrated that physical activity and compounds found in Celery have anti-cancer effects, this study aimed to investigate the interactive effects of eight weeks massage therapy along with celery seed supplementation on the levels of IGF-1 and P53 in overweight women. Method: In a single, blind, placebo-controlled clinical trial, the interactive effects of eight weeks massage therapy along with celery seed consumption on IGF-1 and P53 serum concentrations in overweight women were measured. For this purpose, 28 overweight women with a BMI of more than 25 kg/m2 in Ghaemshahr were randomly divided into four groups. Weight and serum levels variables of IGF-1 and P53, prior and after the therapy were measured. Then the data were analyzed using t-test and one-way variance analysis. P<0.05 was considered as the level of significance Results: At the end of the study, the average of weight and level of IGF-1 and P53 in experimental groups (massage therapy, Therapy and supplementation, Supplementation) were decreased. There was a significant difference between the weight (P=0.003), the level of IGF-1 (P <0.001) and P53 (P<0.001) of women before and after the start of the intervention in the experimental group while the control group was not changed. Conclusion: The results show that massage therapy along with celery seed supplements, especially the combination of these two non-pharmaceutical approaches have beneficial effects on body weight and IGF-1 and P53 levels in overweight women.

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Background and Objectives: Cardiac massage is the first and most important step during Cardio Pulmonary Resuscitation (CPR). Effective massage restores blood flow to the brain and heart and plays a remarkable role in a successful CPR. Exhaustion of treatment team during resuscitation is one of the factors which may lead to reduced quality of resuscitation massages or failure in some cases. The aim of this study was to design, construct and evaluate a new cardiac massage facilitator to improve the quality of CPR in adult patients.

Methods: In this study, the massage facilitator was designed and registered as a glove which was worn by rescuers during cardiac massage (number of invention: 80797). A load cell sensor was placed under the surface of the glove and the facilitator could be displayed number and depth of massage in centimeters. In order to evaluate the efficiency of the designed system, an experimental study was conducted among 30 emergency students. All statistical analyses were performed by SPSS 19 software using Pearson correlation and independent sample t-test. P-values lower than  0.05 were considered to be significant.

Results: The mean age of all participants was 23.41±2.02 years, the mean height was 175±4.43 centimeters and the mean weight was 65.45±5.02 kilograms. The instrument validity was evaluated using standard validation method of concurrent validity. Our findings revealed a significant correlation between the cardiac massage facilitator and Sim Pad system (more than 0.9). Accordingly, the validity of cardiac massage facilitator was confirmed. While assessing the efficient massage criteria during cardiac massage facilitator utilization, the massage possessed suitable depth (less than 5 cm) in 98% of participants. The numbers of massages were at least 100 massages per minute in 93% of participants.

Conclusion: The results showed that designed system could be used as an effective tool to improve quality of cardiac massage in CPR.