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Manijeh Jalilvand, Reza Najafipoor, Mohammad Shekari, Mana Oloomi, Safar Ali Alizadeh, Abdolazim Nejatizadeh,
Volume 3, Issue 1 (5-2015)
Abstract

Background & Objectives: Breast cancer is the most common cancer among women and the second most common cause of cancer death. Genetic factors play an important role in the development of breast cancer. Among these genetic factors, CHEk2 (checkpoint kinase 2) gene, as a tumor suppressor gene, plays a critical role in DNA repair. Germline mutations in CEHK2 result in the loss of this feature. One of the mutations in CHEK2 gene is a 5395 bp deletion mutation which has been associated with the increasing risk of Breast Cancer in some populations in the world.  In the present study, we investigated the association between a 5395 bp deletion mutation in CHEK2 gene and the risk of Breast Cancer in the women of an Iranian population.

Methods: Pathologic information of 38 cases under the age of 45 and 62 cases over the age of 45 referring to surgery ward of Milad Hospital in Tehran were extracted. 100 healthy controls were included in the study as well. After obtaining informed consent, 5 mL whole blood was taken DNA was successfully isolated. Multiplex PCR was used to investigate the association between a 5395bp deletion mutation in CHEK2 gene and increasing risk of Breast Cancer among patients.

Results: The 5395bp deletion mutation in CHEK2 gene was not found in any of the participating groups of patients or heathy controls.

Conclusion: The present study revealed that there is no significant relation between increasing the risk of Breast Cancer and bearing large deletion mutation in exon 9 and exon 10 of CHECK2 gene.


Zahra Bahrololoomi, Tahereh Sadeghieh, Nahid Maghsoodi, Shirin Pajouhandeh,
Volume 9, Issue 4 (12-2021)
Abstract

Background and Objective: Children’s dental fear is one of the most important challenges that pediatric dentistry faces. Several factors play an important role in children’s dental fear. Home quarantine, changes in routine life and economic disadvantages have resulted in emotional changes in parents and children during COVID-19 pandemic. The aim of this study is to evaluate the levels of children’s dental fear, parental anxiety and their possible correlation during the COVID-19 pandemic.
Material and Methods: The present cross-sectional study comprised one hundred and four children aged 6-12-year-old and their parents. The level of parental anxiety was evaluated using Spielberger state-trait anxiety inventory. CFSS-DS (Children Fear Schedule Survey-Dental Subscale) questionnaire assessed the child’s dental fear. Independent t-test, ANOVA and Pearson correlation coefficient were used for data analysis.
Results: There were significant correlations between the level of parent’s state and trait anxiety and child’s dental fear (respectively P value=0.009 and P value=0.000). However girls showed insignificant higher levels of dental fear compared with boys (P value=0.175), children younger than 9 years old and children with a previous dental treatment had significantly higher dental fear scores (respectively P value=0.006 and P value=0.002). Age, gender and level of education did not show a significant effect on the level of parental anxiety (respectively P value=0.630, P value=0.874 and P value=0.198).
Conclusion: The study has resulted in a significant correlation between parental state-trait anxiety and children’s dental fear.

Zahra Bahrololoomi, Fateme Mehravar, Niloofar Halvani, Hamed Saeid,
Volume 10, Issue 2 (5-2022)
Abstract

Background and objectives: Microleakage at the interface of tooth structure and fissure sealant plays a crucial role in failure of the treatment. This in vitro study aimed to determine the microleakage of self-adhesive flowable composite resins as pit and fissure sealants.
Material and Methods: 60 healthy extracted premolar teeth were randomly divided into the 4 groups (n=15), group 1) clinpro sealants (control), group 2) flowable composite resin with bonding agent (total-etch), group 3) flowable composite resin with self-etch bonding agent, and group 4) self-adhesive composite resin. After thermocycling the specimens were immersed in 2% methylene blue for 48 hours and then sectioned in the buccolingual direction. The microleakage was assessed by dye penetration using a stereomicroscope at 15X magnification. Data analysis was performed using SPSS version 18.0 as well as Mann-Whitney and Kruskal-Wallis tests.
Results: There was a statistically significant difference in microleakage score between the groups (P-value = 0.006). The lowest mean of microleakage level was observed in the flowable composite group with total-etch bonding (group 2) 1.26±0.96, followed by the Clinpro sealant group (group 1) 1.62±1.20, and then the self-adhesive composite group (group 4) 1.85±1.00.
Conclusion: Based on the results of this study, the microleakage of self-adhesive composite resin revealed no significant difference with conventional fissure sealant; however, the microleakage of these composite resin was higher than flowable composite resin with total-etch bonding agent.


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