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Showing 5 results for Moradi

Monavar Moradian Sorkhkalaee, Hasan Eftekhar, Saharnaz Nejat, Narges Saeepour, Sima Esmaeel Shemirzadi,
Volume 1, Issue 1 (10-2012)
Abstract

Background and objective:

Students are the most dynamic people in the society and their health is to a great extent a prerequisite for the health of most individuals in the society. This study was conducted to investigate the state of mental health and factors which influence it in the students of Tehran University of Medical Sciences and Health Services.

Materials and Methods:

This descriptive-analytic study was conducted on 400 students of Tehran Medical Sciences University in the academic year 2010-2011. The number of studied subjects was determined according to the student population of each faculty and questionnaires were randomly distributed among them. The data collection tool in this study was the standard GHQ28 questionnaire. After collecting the data, analysis was done using SPSS.18 software, Chi-square test, T-test, and Regression Logestic.

Results:

25.52% of the attendants were healthy and 75.47% had suspected mental disorders. Also, regarding depression, 75.53% of people suffered from mental disorders and 25.46% were healthy.

Conclusion:

According to the achieved results, it seems that studying at university, facing educational problems and the existing conditions at university cause an increase in the rate of mental disorder among the students of Medical Sciences University.
Morteza Mansoorian, Babak Rastegari-Mehr, Mostafa Ghorbani, Zahra Shafieian, Omid Safari, Sara Moradi, Zahra Delshadi, Aziz Rezapour, Hossein Ansari, Hamid Asayesh,
Volume 3, Issue 1 (5-2015)
Abstract

Background & Objective: Using internet have had a significant impact on the lifestyle changes of internet clients which can affect their health. The aim of this study was to survey the relationship between lifestyle related to internet with loneliness and social support of the internet clients in Ilam University of medical sciences.

Methods: This study was a cross sectional study which was performed in 2014 on 400 university students and personnel of Ilam University of medical sciences using stratified random sampling method.Data collection instrument was a questionnaire comprising of four sections: demographic information, lifestyle related to internet questionnaire , loneliness and social supports questionnaires.All data were analyzed using SPSS software by Mann Withney and Kruscall- Wallis tests and linear regression test.

Results: The linear regression results showed that there was a significant relationship between loneliness and lifestyle related to the internet, gender, marital status, occupational statues and age (P<0.01). There was also a significant relationship between social support and lifestyle related to the internet and age (P<0/05). The results showed that there was a significant relationship between loneliness and social support with marital status, educational degree and internet usage (P<0/01).

Conclusion: According to the significant relation between loneliness and social support with the lifestyle related to the internet, and regarding the inevitability of Internet, it seems more supporting the students and implementing the educational programs for university clients about suitable using of internet is necessary.


Towhid Babazadeh, Morteza Banaye Jeddi, Davood Shojaeizadeh, Fatemeh Moradi, Katayoon Mirzaeian, Elham Gheysvandi,
Volume 4, Issue 2 (10-2016)
Abstract

Background and Objectives: Family-centered empowerment model is one of the patterns in the area of empowering patients in modification of risky behaviors. According to extensive health and economic consequences of brucellosis in the community, we decided to evaluate the effect of this pattern in risk behavior modification in patients with brucellosis.

Methods: The current study was a quasi-experimental study that was performed on 76 individuals with brucellosis in Chalderan County, 2013. All of the patients were allocated in intervention and control groups using stratified randomiztion. Data was collected using a standardized researcher-made questionnaire based on family-centered empowerment model in five structures including knowledge, attitudes, self-efficacy, self-esteem and behavior in two phases. The first stage was before the educational intervention and the second stage was performed two months after the intervention. To analyze data statistically, descriptive statistics and paired and independent t tests with the significance level of 0.05 were used.

Results: Mean and standard deviation of the patients' ages was 37.9 ± 14.7. Paired t-test results showed that the mean scores of knowledge (p<0.001), attitudes (p<0.001), self efficacy (p<0.001), self-esteem (p<0.001) and behavior (p<0.001) were significantly increased within the intervention group. However, the changes were not significant in the mean scores of knowledge (p=0.293), attitudes (p=0.106), self efficacy (p=0.225), self-esteem (p=0.105) and behavior (p=0.303) in the control group. According to the results of independent t-test, the mean scores increased considerably in all structures within the intervention group in comparison to the control group after the educational intervention (p<0.05).

Conclusion: Regular interventional programs and applying educational theories could be an effective method  in high risk behavior modification in patients with brucellosis. Therefore, such  programs should be implemented in a wide range.


Zohreh Hosseini Marznaki, Zainab Alimoradi, Mohammad Hossein Hakimi, Maryam Haghighi, Samad Karkhah,
Volume 10, Issue 2 (5-2022)
Abstract

Background and objectives: One of the potentially effective methods for relieving postpartum perineal pain is auricular acupressure. This review aimed to evaluate the clinical effect of auricular acupressure on postpartum perineal pain in a systematic review.
Material and Methods: An extensive systematic search was performed on online electronic databases, including Scopus, PubMed/MEDLINE, ProQuest, Web of Science, and Cochrane using the keywords related to the purpose, from the earliest to June 30, 2021.
Results: Of 263 articles, three studies were included in the review. A total of 386 women with a mean age of 29.79 years were included in the review. Of the participants, 192 women were in the intervention group. Of the studies included, two studies evaluated auricular acupressure, and one study evaluated battlefield auricular acupuncture plus standard analgesia. Overall, the number of acupressure points varied from 3 to 5. In most cases, auricular acupressure was used at points of Shen Men (n=3) and the external genital area (n=2). Overall, auricular acupressure in one study out of three studies had a significant effect on reducing postpartum perineal pain. Two out of three studies reported no side effects of auricular acupressure for participants.
Conclusion: It seems that auricular acupressure can be used as a simple, low-cost, and practical intervention to reduce postpartum perineal pain. However, future well-designed studies are needed to confirm the findings of this systematic review.

Saeed Pirmoradi,
Volume 11, Issue 1 (7-2023)
Abstract

Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by decreased cognitive function in patients due to forming Aβ peptides and neurofibrillary tangles (NFT) in the brain. Therefore, the need to develop new treatments can reduce this risk. Acetylcholinesterase is one of the targets used in the design of new drugs for the treatment of AD. The researchers obtain new inhibitory ligands based on natural compounds from various medicinal plants, such as the family of Asteroideace, Malvacea, Zingbracea, Hypericacea, and Ebenacea, for treating Alzheimer’s disease. 
Methods: After selecting the reference compound of the enzyme acetylcholinesterase inhibitor with the help of bioinformatics tools such as pharmit and ZINCPHARMER for virtual search through the structural and pharmacologic properties of the reference inhibitor compound, several thousand natural structures of several serious ligands were obtained. Then, the ligands were compared by examining the docking process with the acetylcholinesterase enzyme, and their interactions were visualized with the help of Discovery Studio. Then, the top selected ligands in terms of toxicity, allergy, toxicity, and ADME prediction were evaluated with tools such as molsoft, PKCSM, ADMEtlab2.0, Swiss ADME.
Results: The results revealed that these obtained ligands, like donepezil, have the ability of favorable interactions with different amino acids, the crucial of which are HIS381, TRP385, and GLN527 of AChE, and they all fall in the active site or binding pocket of the active site. The present docking supports this hypothesis that these compounds are possible and valuable small molecule ligands for targeting/inhibiting acetylcholinesterases. Indicatively, according to the binding free energy calculation results, it can be concluded that these ligands can compete with donepezil and affect the formation of acetylcholinesterase complexes. Cholinesterase/donepezil can have an excellent competitive inhibitory effect on it.
Conclusion: On the other hand, the study on the designed ligands showed that with favorable interactions and lower binding energy, they form more stable complexes with acetylcholinesterase and can be proposed as inhibitors competing with donepezil in a bind to this enzyme.


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