Jorjani Biomedicine Journal

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  Abstract

  Background and objectives: Depression is the most common cause of disability caused by diseases in the world. Having physical activity is a solution for reducing depression. This study was conducted to determine the causes of depression and its related factors.

  Methods: In this descriptive-analytical study, 266 female students participated in the study selected by random stratified sampling. The data were collected with demographic questionnaires, the Beck Depression Inventory, and the International Physical Activity Questionnaire (IPAQ) and the body composition was measured with the body analyzer machine and entered into the SPSS software. To examine the effect of physical activity on depression, a logistic regression model was used with adjusting the effect of the likely confounding variables.

  Results: The mean age of the participants was 22.15 ± 2.4. According to the Beck Depression Inventory, 24.8% (66 individuals) suffered from depression and 69.5% (185 individuals) were healthy and 5.6% (15 persons) were missing from study. The results did not show a significant difference between depression and being local or nonlocal, BMI and the income level. But there was a significant difference between the healthy and the depressed group with regard to physical activity ( P=0.03). Physical activity at recommended levels showed an inverse relationship with depression of students so that students who have the recommended levels of physical activity get the 44% lower chance to be in the depressed group against students who have been low level of physical activity (OR=0.56, 95% CI:0.31-0.99, P=0.046).

  Conclusion: Due to the effect of physical activity on reducing depression, providing sport facilities, recommending people to increase their physical activity and culture making in the society can serve as constructive solutions to improving the psychological health and preventing depression in the society.

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Background & objective: But its etiology is unknown. Based on deficiency of epidemiological studies, this study Family and genetic factors are effective on incidence of external hydrocephalus aimed to determine the demographic features of children with external hydrocephalus.

Methods: Referred to Taleghani tertiary hospital during 2009-2011 were assessed. Inclusion criteria In this retrospective descriptive study (2011), all records of children with external hydrocephalus was definite diagnosis of external hydrocephalus. Checklist was used for data collection. All data were entered to SPSS software (version 16) and were described by descriptive statistics.

Results: (48.8%), 32 cases born by cesarean section (78%), 31 cases (75.6%) with no consanguineous marriage of parents, 38 cases (92.7%) born at term gestational age, 24 cases (58.53%) with macrocephaly in family, 17 cases (41.5%) with hospitalization history, 39 cases (95.1) with normal birth weight were assessed. Mean of age and head circumference were 8.8±2.8 years and 35.15±1.5 cm, respectively. Increase of head circumference with 30.2 % was the most common complaint at referred time during health cares. 33 cases (80.5%) diagnosed based on CT scan and 11 cases (26.8%) had development delay. From 41 children included to the study, 33 boys (80.5%), 20 cases with Fars ethnicity

Conclusion: Of head circumference during health cares had the most frequency of external hydrocephalus. Much more attention to these children and early diagnosis and treatment is essential. Boys children with fars ethnicity, macrocephaly history, developmental delay and increase.

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Background and objectives:

Almost 130 million infants are born each year, more than 8 million of whom

die before their first year of life. In the developing countries, two thirds of these deaths occur in the first month

of their life. Reduced infant mortality is among the Millennium Development indicators, and this rate is high

in Kalaleh city. This study aimed to identify the most common causes of infant death, so that the avoidable

deaths be prevented by offering intervention plans.

Methods:

information was collected with the designed form. The data were, then, coded and entered into the SPSS 17

software, and analyzed using independent statistical chi-square test.

In this study, all causes of infant death in Kalaleh city during 2003-2013 were investigated. The

Results:

prematurity (47.42%), congenital abnormalities (22.42%), and disasters and accidents (9.79%). 82.73%

of the infants weighed below 2500 g. 60% of the prematurity deaths occurred to primigravid women. There

388 infant deaths accounted for 83% of under-5 mortality. The most common causes of death include

was a statistically significant relationship between primigravity and prematurity infant death with a 95% confidence

(P=0.003). 74.74% of the infant deaths occurred in the first week, and 58.96% in the first 24 hours.

Conclusion:

As 38.4% of the infant deaths occurred in the first pregnancy, and 60% of prematurity deaths

happened to primigravid women, and there was a relationship between primigravity and prematurity infant

deaths, the importance of the particular care of these mothers comes into sight. Planning for teaching the im

of caring the primigravid mothers and making their families more sensitive about the significance of

portance

caring these mothers can be effective in reducing premature infant mortality.

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Background & Objective: Dyslipidemia increases the risk of developing cardiovascular diseases in diabetic patients. Lipoprotein a, as a cholesterol carrier and competitive inhibitor of plasminogen in the blood coagulation system is considered an atherogenic factor which increases the risk of developing atherosclerosis in diabetic individuals. Based on previous studies, Barberry is thought to lower cholesterol and triglyceride levels. Since increased cholesterol level, especially Lipoprotein a, increases the risk of cardiovascular diseases in people with diabetes, the aim of this study was to evaluate serum levels of Lipoprotein (a) in diabetic rats treated with aqueous extract of Barberry. Method: In this experimental study, diabetes was induced in 15 mice by intraperitoneal injection of streptozotocin (STZ) and then they were treated orally for 14 days with liquid extract of the said plant in doses of 25 and 100 mg/kg. At the end of the treatment period, mice were kept fasted for 12 hours and then by heart phlebotomy, serum levels of Lipoprotein a, serum levels of glucose, triglycerides, total cholesterol, HDL and LDL were measured in normal and diabetic groups. The results were then analyzed using SPSS version 16, ANOVA and Tukey›s test. Results: Data analysis showed that the consumption of both oral doses of Berberis vulgaris (Barberry) in diabetic rats causes a significant reduction in serum levels of triglyceride, serum glucose and VLDL(P=0.01). The extract at both used doses also significantly reduced serum levels of lipoprotein (a) in treated diabetic rats (P=0.012). Conclusion: Oral administration of the aqueous extract of Berberis vulgaris (Barberry) is effective for reducing triglyceride and glucose levels in diabetic mice. Since Barberry lowers Lipoprotein (a) levels, it can be considered as an anti-atherogenic factor.

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Background & Objective: High blood levels of IGF-1 in women before menopause, is a risk factor and P53 tumor suppressor gene is also one of the most common genes involved in breast cancer. Since some studies demonstrated that physical activity and compounds found in Celery have anti-cancer effects, this study aimed to investigate the interactive effects of eight weeks massage therapy along with celery seed supplementation on the levels of IGF-1 and P53 in overweight women. Method: In a single, blind, placebo-controlled clinical trial, the interactive effects of eight weeks massage therapy along with celery seed consumption on IGF-1 and P53 serum concentrations in overweight women were measured. For this purpose, 28 overweight women with a BMI of more than 25 kg/m2 in Ghaemshahr were randomly divided into four groups. Weight and serum levels variables of IGF-1 and P53, prior and after the therapy were measured. Then the data were analyzed using t-test and one-way variance analysis. P<0.05 was considered as the level of significance Results: At the end of the study, the average of weight and level of IGF-1 and P53 in experimental groups (massage therapy, Therapy and supplementation, Supplementation) were decreased. There was a significant difference between the weight (P=0.003), the level of IGF-1 (P <0.001) and P53 (P<0.001) of women before and after the start of the intervention in the experimental group while the control group was not changed. Conclusion: The results show that massage therapy along with celery seed supplements, especially the combination of these two non-pharmaceutical approaches have beneficial effects on body weight and IGF-1 and P53 levels in overweight women.

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Background & Objective: Beta-thalassemia major, impairs body and central nervous system functions. Decline in Perceptual and cognitive abilities in this disease, especially in children, and eventual reduced quality of life, is one of the possible complications of this disease. The purpose of this study was to evaluate the cognitive perception of two abilities to think abstractly and visual organization in children with beta-thalassemia major and healthy counterparts. Method: This cross-sectional study was conducted in year 1391, using convenient sampling in cities of Zahedan and Shiraz. After matching children in terms of age, gender and city of residence, 40 children with beta-thalassemia major and 40 matched healthy children aged 6-12 years were compared, using the independent t-test and Wechsler Intelligence Scale for Children revision (WISC-R) in terms of abstract thinking and visual organization. Results: There was a statistically significant difference in evaluation of abstract thinking between the average score of sick children 9.81 ± 1.64 and the average score of healthy counterparts 10.82 ± 1.05 (P<0.01). Also in assessment of visual organization, the average score of sick children 10.23 ± 1.09 and the average score of healthy counterparts 10.72 ± 0.66 were significantly different(P<0.01). Conclusion: The results show the potential impact of the disease on children›s cognitive levels and suggest that children with beta-thalassemia major need more attention in the field of education to promote their understanding.

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Background & Objective: Control of hypertension is based on lifestyle modification. Group discussion can be considered as an efficient method for health education. Therefore, this study was aimed to determine the effect of group discussion on the empowerment of patients with hypertension who were referred to two health centers in Tehran. Method: This was a pretest-post test, quasi-experimental study in a group. The convenience sampling method was used by randomly selecting 36 patients with primary hypertension, aged 30-65 years. They were divided into 4 groups of 9 people. Since the comparison of groups was not taken into consideration, they were not homogenized. For each group, six 90-minute group discussion sessions were held. The tools included demographic information checklists and verbal empowerment questionnaire of Elhani et al with the scale of perceived intensity, perceived susceptibility, efficacy, and control axis. The data were calculated and analyzed using descriptive statistics and paired t-test. Results: The average age of the subjects was 54 ± 8.4 years and 34.4% of the participants had a history of hypertension for 5 years. Group discussions could lead to improve the average empowerment of individuals (P=0.04). Furthermore, among all the aspects of empowerment, group discussions had the greatest impact on the perception and sensitivity levels (P=0.001 and P=0.02 respectively). Conclusion: In patients with hypertension, group discussions can lead to increased perception and sensitivity levels and also enhance the ability of individuals to control their lifestyles.

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Background & Objective: Myocardial infarction is one of the most common coronary artery diseases. One of the educational needs of patients, is how to perform sexual activities. Unfortunately, this issue is not being taught to patients, leading to problems in patients and their partners. This study was aimed to determine the effect of sex education on patients and their spouses› satisfaction after myocardial infarction. Method: This Quasi-experimental, non-randomized study was performed on 60 patients with myocardial infarction and their spouses in the city of Yazd whom were divided into two groups of experimental and control (60 in each group),in the year 1392. The main method of this study was the education and preparation of nurses and then educating patients by trained nurses and to assess sexual satisfaction based on the standard Larson›s questionnaire. The data were then statistically analyzed using SPSS version 16 using paired, independent t-test. Results: The average sexual satisfaction of patients in the experimental group before the intervention was 81.93 ± 12.47 and after the intervention 82.50 ± 12.57 While in the control group before the intervention the average satisfaction was 83.10 ± 17.36 and after 6 weeks 75.30 ± 15.42. Also the mean sexual satisfaction of partners in the test group before and after the intervention was 81.30 ± 12.47 and 82.07 ± 12.28 respectively. In the control group before the intervention, the average score was 82.50 ± 17.21 and after intervention it was 74.57 ± 15.30. There was significant difference between patients and spouses› sexual satisfaction scores in the experimental and control groups before and after the intervention (P=0.001). Conclusion: Sex education increased the sexual satisfaction among the tested group. Therefore, it is suggested to include programs in order to prepare nurses in terms of sex education of patients and their spouses in cardiac intensive wards.

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Background & Objective: Health promotion is defined as the process of enabling people to increase control over their behavior and health improvement. Among all these, health promoting behaviors are one of the best ways by which people can maintain and control their health. Due to the importance of young adults› health in promoting health in the community, This study aimed to determine and compare the health promoting behaviors in the first and fourth year students of Shahid Beheshti University of Medical and non-Medical Sciences in the academic year 92-93. Method: This cross-sectional study was carried on 500 students from the two Shahid Beheshti Universities by multistage sampling. Data were collected by the 52-item questionnaire of Health-Promoting Lifestyle Profile II. The data were analyzed using SPSS version 18, independent t-test, Pearson correlation, multiple regression analysis and ANOVA analysis. Results: The results showed that from the total score of 208, the average and standard deviation of health promoting behaviors was 128.74 ± 20.16 in students of medical sciences and 128.96 ± 20.52 in non-medical students. Among all the aspects of health promoting behaviors on the two tested groups, self-actualization and physical activity had the highest and lowest scores respectively. Conclusion: In this study, there was no statistically significant difference between the average score of health promoting behaviors among medical and non-medical students.

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Background & Objective: Head lice infestation is a common disease in all ages with a worldwide distribution with considerable frequency in community centers such as schools. This study was aimed to determine the prevalence of head lice infestation and it›s affecting factors in the rural school students of Kalaleh, in the academic year 92-93. Method: This study was a cross sectional, descriptive-analytic approach. The studied population consisted of 2500 students in rural schools of Kalaleh, studying in the academic year 1392-93. Data were collected via direct observation of experts and the checklist of Pediculosis. Data were then entered into and analyzed using SPSS version 17. Results: 157 of students (6.28%) had head lice with the highest frequency among the girls with 147 people. There was a statistically significant relationship between the place of residence, occupation, education level of parents, family size, education level, existence of a shower in homes, frequency of showering and brushing, a history of head lice infestation, the presence or absence of school health teachers and hair size (P<0.05). Conclusion: Pediculosis is still a public health problem in communities with poor life and health facilities. High prevalence of this issue among school students may be linked to factors such as lack of health educators in school and lack of adequate attention to personal hygiene.

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Background & Objective: Deafness is the most common sensory disorder in humans which is highly heterogeneous. Among its various types, autosomal recessive non-syndromic hearing loss (ARNSHL) is responsible for 80% of pre-speech congenital cases of hearing loss. The purpose of this study was to investigate the genetic linkage of DFNB4 locus in hearing impaired families in Hormozgan. Method: Ten deaf large families in the Hormozgan province were selected. A hearing impaired person was selected from each family tree and sequence of the GJB2 gene in regards of coding regions' mutations was investigated using sequencing method. STR markers of DFNB4 locus in families with no mutation in GJB2 were amplified using PCR and after determining the type alleles, they were analyzed for linkage. Results: In one among the ten studied families, GJB2 mutation was observed. The nine other families were entered for linkage studies and no linkage was found in the said families. Conclusion: Due to the high heterogeneity of loci associated with ARNSHL, other factors may be involved in the cause of deafness in families, without mutations in the GJB2 gene and the investigated locus. Therefore it is recommended to study other loci and more families in this matter.

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Background & Objective: Cattle Slaughterhouses are one of the main centers of wastewater producing facilities with high pollution load, which in the absence of proper treatment can cause a lot of environmental pollution. The aim of this study was to determine the effectiveness of Industrial slaughterhouse wastewater treatment plant in the city of Sanandaj in 2012. Method: This is a cross-sectional study which was conducted in the laboratory of faculty of health, university of medical sciences in Sanandaj in the year 2012 for three months. Weekly tests of chemical oxygen demand (COD), biochemical oxygen demand (BOD) and total suspended solids (TSS) and in total 24 times sampling of input and output for the treatment plant was performed instantly. The experiments were based on the latest proposed method in the book of standard method (the Examination of Water and Wastewater) and at the end, Microsoft EXCEL software was used for data analysis. Results: The average COD, BOD and TSS entering the plant were 2036.69 ± 61, 1216.5 ± 220 and 791.12 ± 147 milligrams per liter and their average output from the plant were 747.71 ± 17, 517.5 ± 8 and 306.51 ± 8 milligrams per liter and the total average of removal efficiency for each of these parameters were 63.29 ± 3 percent, 57.45 ± 2 percent and 61.25 ± 5 percentage respectively. Conclusion: The quality of output effluent from treatment plant of cattle slaughterhouse in Sanandaj, in almost all months was not according to effluent disposal standards and generally, the efficiency of this treatment plant is not desirable in removal of contaminants. Therefore, its efficiency should be improved by using appropriate methods.

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Background & Objective: Citrinin mycotoxin is produced by filamentous toxin producing fungi. Saccharomyces cerevisiae yeast has the ability to bind mycotoxins to its cell wall and thus reduce its toxicity. The aim of this study was to determine the amount of Citrinin mycotoxin and its reduction in wheat flour by Saccharomyces cerevisiae. Method: In this study, 15 samples of wheat flour were randomly collected from the bakeries in the city of Babol. The amount of Citrinin contamination in samples was assessed by direct competitive ELISA measurement and then Saccharomyces cerevisiae was added to wheat flour. The amount of Citrinin contamination in the samples was measured by direct competetive ELISA for a second time. SPSS software (version 18), Kolmogrov-Smirnov test and paired t-test was used for statistical analysis of data. The significance level for all tests was considered less than 0.05. Results: The highest and lowest concentration of this toxin in the studied samples were 35.5 and 1.1 ppb respectively, and after the effect of Saccharomyces cerevisiae on wheat flour, 0.8 and 30 ppb respectively. The statistical results showed that the addition of Saccharomyces cerevisiae decreased the amount of Citrinin in flour samples (P<0.05). Conclusion: Bread is among the most important and necessary food. To reduce its contaminating materials such as mycotoxins, less expensive and safe biological methods can be used.

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Background & Objective: Job burnout is one of the inevitable consequences of occupational stress. Professional staff of social services are the first candidates of burnout, therefore this study was aimed to determine the relationship between occupational stresses with job burnout in pre-hospital emergency staff. Method: In this cross-sectional study, 206 employees, working in 44 pre-hospital emergency bases in Golestan province were enrolled in years 2011-12. Information was obtained by occupational stress questionnaire and Maslach Burnout and then using descriptive statistics, Pearson correlation coefficient test, ANOVA, T-Test and Tukey tests the data were analyzed in SPSS software. Results: 117 individuals (75.5 percent) had moderate to high stress. Organizational factors (21.62 ± 6.05) with a mean score from 100 (65.51) had the highest score in causing stress and physical factors (10.44 ± 3.43), occupational (37.12 ± 1.12) and group factors (10.54 ± 1.12) were second and third respectively. Among all the subjects, 76.6% had experienced moderate to high burnout. There was a significant statistical difference between job stress and age (P=0.02) , type of employment (P=0.048) and between burnout and education (P=0.028) in the overall level of job stress and burnout significant correlation was observed (r=0.335, P<0.001). Conclusion: Emergency staffs work in a stressful environment, which leads to burnout, thus identifying stressors and ways to overcome these factors, especially in the corporate (management) dimension can help reduce burnout.

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Background & Objective: Job satisfaction Increases individual efficiency and commitment to the organization, ensuring the physical and mental health, life satisfaction and accelerate the learning of new skills on the job. The aim of this study was to determine the status of health professionals› satisfaction in the Golestan province. Method: In this cross- sectional study, 1,275 health workers of Health centers in the Golestan province in the year 1391 were participated using the census method. Data was collected using Herzberg job satisfaction questionnaire. The data were analyzed using SPSS software, ANOVA and t-Test at the significant level of 0.05. Results: Job satisfaction in terms of staff maintenance and support and given the potential and experience of individuals in granting liability were at dissatisfied level, In terms of corporate communications, career development, salary and benefits, challenges and job management, at relatively dissatisfied and from the aspect of social acceptance level was at relatively satisfied. Job satisfaction was significantly associated with work experience (P=0.049), ethnicity (P=0.009) and city of service location (P=0.001). Conclusion: Due to poor job satisfaction levels, effective actions should be taken to improve organizational communication, career development, salary and benefits, social acceptance, staff maintenance and support, management, Job challenges, and granting responsibilities based on the ability and experience of the individuals.

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Background & Objective: Self-care means enabling individuals to manage special circumstances, such as illness, chronic diseases and having more control over life. Women are more susceptible to serious health risks such as obesity and overweight compared to men, therefore this study was conducted in the city of Gorgan to determine the knowledge, attitude and behavior of women regarding the self-care behavior. Method: In this descriptive- analytical study, 420 women referred to health centers of Gorgan were recruited through cluster random sampling. Data were collected using the standard general self-care questionnaire. Information such as barriers and facilitators of self-care behavior, knowledge, desire and performing self-care behaviors of individuals were evaluated. Data were then analyzed using descriptive statistics and analytical tests in SPSS software (version16). Results: The mean age of samples was 33.07 ± 12.2 years. Among all the tested individuals, 49% (n=206) had a satisfactory knowledge about Self-care, 36.4% (n=152) had a tendency to perform self-care and 21.8 percent (n=92) were performing self-care related activities. There was a significant relationship between knowledge and performing self-care (P= 0.0001), attitudes and performing self-care (P=0.0001) and between knowledge and behavior (P=0.0001). Conclusion: Due to the relative knowledge, attitude and unfavorable performance of individuals, appropriate educational interventions are recommended to increase knowledge. Moreover the awareness and attitude of the participants should also be changed using attitude change techniques such as in-depth interviews and subsequently its improvements will occur.

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Background & Objective: Prediction of health status in newborns and also identification of its affecting factors is of the utmost importance. There are different ways of prediction. In this study, effective models and patterns have been studied using decision tree algorithm. Method: This study was conducted on 1,668 childbirths in three hospitals of Shohada, Omidi and Mehr in city of Behshahr. Variables such as baby's gender, birth weight, birth order, maternal age, maternal history of illness, gestational diseases, type of delivery, reason of caesarean section, maternal age, family relationship of father and mother, mother's blood type, mother's occupation and blood pressure and place of residence were chosen as predictive factors of decision tree categorization method. The health status of the baby was used as a dependent dual-mode variable. All variables were used in clustering and correlation rules. Prediction was done and then compared using 4 decision-tree algorithms. Results: In the clustering method, the optimal number of clusters was determined as 8, using the Dunn index measurement. Among all the implemented algorithms of CART, QUEST, CHAID and C5.0, C5.0 algorithm with detection rate of 94.44% was identified as the best algorithm. By implementing the Apriori algorithm, strong correlation rules were extracted with regard to the threshold for Support and Confidence. Among the characteristics, maternal age, birth weight and reason of caesarean section with the highest impacts were found as the most important factors in the prediction. Conclusion: Due to the simple interpretation of the decision tree and understandability of the extracted rules derived from it, this model can be used for (most individuals) professionals and pregnant women at different levels.

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Launching of the Quarterly Journal of Hakim Seyyed Ismael Jorjani in Golestan University of Medical Sciences and Health Services is appreciated. In this article, it has been tried to address the true life and birthplace of Hakim Seyyed Ismael Jorjani from a historical perspective. It is hoped that this review will enrich this respected scientific journal so that researchers honor and appreciate Iranian scholars and physicians.

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Background & Objectives: Breast cancer is the most common cancer among women and the second most common cause of cancer death. Genetic factors play an important role in the development of breast cancer. Among these genetic factors, CHEk2 (checkpoint kinase 2) gene, as a tumor suppressor gene, plays a critical role in DNA repair. Germline mutations in CEHK2 result in the loss of this feature. One of the mutations in CHEK2 gene is a 5395 bp deletion mutation which has been associated with the increasing risk of Breast Cancer in some populations in the world.  In the present study, we investigated the association between a 5395 bp deletion mutation in CHEK2 gene and the risk of Breast Cancer in the women of an Iranian population.

Methods: Pathologic information of 38 cases under the age of 45 and 62 cases over the age of 45 referring to surgery ward of Milad Hospital in Tehran were extracted. 100 healthy controls were included in the study as well. After obtaining informed consent, 5 mL whole blood was taken DNA was successfully isolated. Multiplex PCR was used to investigate the association between a 5395bp deletion mutation in CHEK2 gene and increasing risk of Breast Cancer among patients.

Results: The 5395bp deletion mutation in CHEK2 gene was not found in any of the participating groups of patients or heathy controls.

Conclusion: The present study revealed that there is no significant relation between increasing the risk of Breast Cancer and bearing large deletion mutation in exon 9 and exon 10 of CHECK2 gene.

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Background and objectives: Fortification of beverages with new functional ingredients such as prebiotics is one of the recent progresses in the field of juice production. Therefore, the objective of the present study was to evaluate the effects of adding some prebiotics such as Inulin and Tagatose on physicochemical and sensory properties of orange juice.

Methods: The prebiotic compounds (Inulin and Tagatose) along with sucrose were added to orange juice in specific proportions and then pasteurized at 90°C. Orange juice treated samples were kept at 4°C (refrigerator temperature) and 25°C (room temperature) for 3 months. Physicochemical (Brix, acidity, sucrose content and pH) and sensory properties of treated samples were evaluated within time intervals of one month.

Results: The results showed that storage temperature had no significant effect on pH, Brix and acidity of all treatments (P>0.05). On the other hand, total sugar content of all treatments had decreased significantly during storage (P<0.05), as the greatest decrease was observed in Inulin-3/Sucrose-3 treatment keeping at room temperature with 33.7%. It was reported that no change in the transparency treatments was observed (P>0.05). Storage of treatments at room temperature had decreased the acceptance of flavors significantly (P<0.05).

Conclusion: The result of this study showed that Inulin in combination with sucrose and Tagatose could be used to produce salutary juice with desirable sensory properties.