دوره 4، شماره 2 - ( پاییز و زمستان 1395 )                   جلد 4 شماره 2 صفحات 20-1 | برگشت به فهرست نسخه ها

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khosrojerdi A, Mashayekhi K, Zare Marzouni H. Curcumin (Extracted from Tumeric) and its Therapeutic Effects. Jorjani Biomed J 2016; 4 (2) :1-20
URL: http://goums.ac.ir/jorjanijournal/article-1-471-fa.html
خسروجردی آرزو، مشایخی کاظم، زارع مرزونی هادی. کورکومین (مستخرج از زردچوبه) و اثرات درمانی آن. فصلنامه علمی پژوهشی زیست پزشکی جرجانی. 1395; 4 (2) :1-20

URL: http://goums.ac.ir/jorjanijournal/article-1-471-fa.html


1- دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
2- دانشگاه علوم پزشکی مشهد، مشهد، ایران
3- دانشگاه علوم پزشکی مشهد، مشهد، ایران.
چکیده:   (16945 مشاهده)

زمینه و هدف: استفاده از داروهای گیاهی در سال‌های اخیر رو به افزایش است. بنابراین تلاش برای بازنگری و احیای این داروهای قدیمی امری منطقی است و شناخت مکانیسم فعالیت آن‌ها می‌تواند منجر به شکل گیری و پذیرش درمان‌های جدید برای بسیاری از بیماری‌ها شود. کورکومین مهم‌ترین جزء تشکیل دهنده زرد چوبه است. هدف از این مقاله، مرور خواص ضد التهابی و ضد میکروبی کورکومین و معرفی آن به عنوان یک مولکول درمانی است.

روش بررسی: در این مطالعه مروری، 121 مقاله حاصل از جستجو در منابع الکترونیکی و کتابخانه ایِ معتبر، نظیر Pubmed، Medline، Science Direct،WOS  ، DOA SID ، Iranmedex، Magiran و موتور جستجوگر Google Scholar استفاده شد. که در آنها کورکومین (زردچوبه) را از جنبه های مختلف درمانی مورد بررسی قرار داده بودند، تدوین شده است.

یافته ها: مطالعات انجام شده نشان دهنده پاسخ های درمانی کارآمد سیستم ایمنی در برابر عوامل التهابی و عفونی با کمک کورکومین می باشد. از مشکلات بیان شده در مصرف خوراکی کورکومین، انحلال بسیار کم در آب و زیست فراهمی پایین آن است که باعث جذب ضعیف از دستگاه گوارش، متابولیزه شدن سریع و حذف آن از سیستم گردش خون می باشد.

نتیجه گیری: بر اساس نتایج این مطالعه مروری، کورکومین دارای خواص ضد التهابی، ضد میکروبی، ضد ویروسی و ضد انگلی بسیار کارآمدی می باشد. با این وجود، زیست فراهمی پایین این ماده خواص درمانی آن را محدود کرده است. امروزه مکانیسم های متعددی برای افزایش این در دسترس بودن زیستی پیشنهاد شده است که می تواند جذب این ماده را بهبود بخشد.

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نوع مقاله: مروری | موضوع مقاله: پزشکی عمومى
دریافت: 1395/10/6 | پذیرش: 1395/10/6 | انتشار: 1395/10/6

فهرست منابع
1. Ainechi Y, Herbal Materia Medica and Iran. Tehran: Publishing and Printing Institute of Tehran University, November 1370, pages 20 to 56
2. Ghasemi dehkordi N, Herbal Pharmacopoeia Iran. Tehran: Ministry of Health and Medical Education, Department of Medicine Ghzarv, March 1381, pages 15 to 30
3. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Advances in experimental medicine and biology. 2007;595:1-75
4. Glusker J. Intermolecular interactions around functional groups in crystals: data for modeling the binding of drugs to biological macromolecules. Acta Crystallographica Section D: Biological Crystallography. 1995;51(4):418-27
5. Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta medica. 1991;57(1):1-7
6. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer research. 2001;21(4B):2895-900
7. Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. Journal of agricultural and food chemistry. 1999;47(10):4297-300
8. Apisariyakul A, Vanittanakom N, Buddhasukh D. Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). Journal of ethnopharmacology. 1995;49(3):163-9
9. Arora RB, Kapoor V, Basu N, Jain AP. Anti-inflammatory studies on Curcuma longa (turmeric). The Indian journal of medical research. 1971;59(8):1289-95
10. Kuo JJ, Chang HH, Tsai TH, Lee TY. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. International journal of molecular medicine. 2012;30(3):673-9
11. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2001;21(21):8370-7
12. Kanitkar M, Gokhale K, Galande S, Bhonde RR. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. British journal of pharmacology. 2008;155(5):702-13
13. Ma C, Ma Z, Fu Q, Ma S. Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice. Fitoterapia. 2013;87:57-64
14. Mei X, Xu D, Xu S, Zheng Y, Xu S. Novel role of Zn(II)-curcumin in enhancing cell proliferation and adjusting proinflammatory cytokine-mediated oxidative damage of ethanol-induced acute gastric ulcers. Chemico-biological interactions. 2012;197(1):31-9
15. Xu YX, Pindolia KR, Janakiraman N, Chapman RA, Gautam SC. Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells. Hematopathology and molecular hematology. 1997;11(1):49-62
16. Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S. Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. Clinical immunology. 1999;93(2):152-61
17. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, et al. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Journal of immunology. 1999;163(6):3474-83
18. Literat A, Su F, Norwicki M, Durand M, Ramanathan R, Jones CA, et al. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life sciences. 2001;70(3):253-67
19. Gao X, Kuo J, Jiang H, Deeb D, Liu Y, Divine G, et al. Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochemical pharmacology. 2004;68(1):51-61
20. Fahey AJ, Adrian Robins R, Constantinescu CS. Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. Journal of cellular and molecular medicine. 2007;11(5):1129-37
21. Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 2004;25(9):1671-9
22. Kaur G, Tirkey N, Bharrhan S, Chanana V, Rishi P, Chopra K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and experimental immunology. 2006;145(2):313-21
23. Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. The Journal of biological chemistry. 2011;286(32):28556-66
24. Chuang SE, Cheng AL, Lin JK, Kuo ML. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2000;38(11):991-5
25. Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways. Acta pharmacologica Sinica. 2013; 34(7)10-11
26. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Molecular nutrition & food research. 2008;52(9):987-94
27. Yun JM, Jialal I, Devaraj S. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. The Journal of nutritional biochemistry. 2011;22(5):450-8
28. Villegas I, Sanchez-Fidalgo S, de la Lastra CA. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Molecular nutrition & food research. 2011;55(2):259-67
29. Abe Y, Hashimoto S, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacological research: the official journal of the Italian Pharmacological Society. 1999;39(1):41-7
30. Kang BY, Song YJ, Kim KM, Choe YK, Hwang SY, Kim TS. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. British journal of pharmacology. 1999;128(2):380-4
31. Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. The American journal of Chinese medicine. 2010; 38(1):99-111
32. Cho YJ, Yi CO, Jeon BT, Jeong YY, Kang GM, Lee JE, et al. Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs. The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2013;17(4):267-74
33. Zhong Y, Liu T, Lai W, Tan Y, Tian D, Guo Z. Heme oxygenase-1-mediated reactive oxygen species reduction is involved in the inhibitory effect of curcumin on lipopolysaccharide-induced monocyte chemoattractant protein-1 production in RAW264.7 macrophages. Molecular medicine reports. 2013;7(1):242-6
34. Rennolds J, Malireddy S, Hassan F, Tridandapani S, Parinandi N, Boyaka PN, et al. Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium. Biochemical and biophysical research communications. 2012;417(1):256-61
35. Gonzales AM, Orlando RA. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutrition & metabolism. 2008; 5:17
36. Grandjean-Laquerriere A, Gangloff SC, Le Naour R, Trentesaux C, Hornebeck W, Guenounou M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine. 2002;18(3):168-77
37. Gu Y, Lee HM, Napolitano N, Clemens M, Zhang Y, Sorsa T, et al. 4-methoxycarbonyl curcumin: a unique inhibitor of both inflammatory mediators and periodontal inflammation. Mediators of inflammation. 2013; 329:740
38. Cheppudira B, Fowler M, McGhee L, Greer A, Mares A, Petz L, et al. Curcumin: a novel therapeutic for burn pain and wound healing. Expert opinion on investigational drugs. 2013;22(10):1295-303
39. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 1998;6(2):167-77
40. Mani H, Sidhu GS, Kumari R, Gaddipati JP, Seth P, Maheshwari RK. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. BioFactors. 2002;16(1-2):29-43
41. Kliem C, Merling A, Giaisi M, Kohler R, Krammer PH, Li-Weber M. Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation. The Journal of biological chemistry. 2012;287(13):10200-9
42. Ranjan D, Chen C, Johnston TD, Jeon H, Nagabhushan M. Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling. The Journal of surgical research. 2004;121(2):171-7
43. Chueh SC, Lai MK, Liu IS, Teng FC, Chen J. Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions. Transplantation proceedings. 2003;35(4):1603-5
44. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. International journal of clinical pharmacology, therapy, and toxicology. 1986;24(12):651-4
45. Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacology and immunotoxicology. 2003;25(2):213-24
46. Huang WT, Niu KC, Chang CK, Lin MT, Chang CP. Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits. European journal of pharmacology. 2008;593(1-3):105-11
47. Manjunatha H, Srinivasan K. Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats. The FEBS journal. 2006;273(19):4528-37
48. Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. Journal of agricultural and food chemistry. 2007;55(25):10150-5
49. Buyuklu M, Mehmet Kandemir F, Ozkaraca M, Set T, Murat Bakirci E, Topal E. Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis? European review for medical and pharmacological sciences. 2014;18(4):461-70
50. Ueki M, Ueno M, Morishita J, Maekawa N. Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. Journal of bioscience and bioengineering. 2013;115(5):547-51
51. Ghosh SS, Massey HD, Krieg R, Fazelbhoy ZA, Ghosh S, Sica DA, et al. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation. American journal of physiology Renal physiology. 2009;296(5):F1146-57
52. Ghosh SS, Krieg R, Massey HD, Sica DA, Fakhry I, Ghosh S, et al. Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. American journal of physiology Renal physiology. 2012;302(4):F439-54
53. Zhong F, Chen H, Han L, Jin Y, Wang W. Curcumin attenuates lipopolysaccharide-induced renal inflammation. Biological & pharmaceutical bulletin. 2011;34(2):226-32
54. Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K, et al. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Molecular nutrition & food research. 2013;57(9):1649-59
55. Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, et al. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochemical and biophysical research communications. 2008;375(2):275-9
56. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, et al. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 2009;30(11):1949-56
57. Bansal S, Chhibber S. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice. Journal of medical microbiology. 2010;59(Pt 4):429-37
58. Oh SW, Cha JY, Jung JE, Chang BC, Kwon HJ, Lee BR, et al. Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-kappaB inhibition. Journal of ethnopharmacology. 2011;136(3):414-21
59. Narumoto O, Matsuo Y, Sakaguchi M, Shoji S, Yamashita N, Schubert D, et al. Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling. Experimental and molecular pathology. 2012;93(1):18-25
60. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology. 2008;149(7):3549-58
61. Kowluru RA, Kanwar M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutrition & metabolism. 2007;4:8
62. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annual review of nutrition. 2010;30:173-99
63. Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Annals of the New York Academy of Sciences. 2009;1171:428-35
64. Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis research & therapy. 2009;11(6):R165
65. Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Digestive diseases and sciences. 2005;50(11):2191-3
66. Lubbad A, Oriowo MA, Khan I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Molecular and cellular biochemistry. 2009;322(1-2):127-35
67. Bereswill S, Munoz M, Fischer A, Plickert R, Haag LM, Otto B, et al. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PloS one. 2010;5(12):e15099
68. Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, et al. The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. The British journal of nutrition. 2009;101(2):169-81
69. Suskind DL, Wahbeh G, Burpee T, Cohen M, Christie D, Weber W. Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study. Journal of pediatric gastroenterology and nutrition. 2013;56(3):277-9
70. Naik SR, Thakare VN, Patil SR. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie. 2011;63(5):419-31
71. Patro BS, Rele S, Chintalwar GJ, Chattopadhyay S, Adhikari S, Mukherjee T. Protective activities of some phenolic 1,3-diketones against lipid peroxidation: possible involvement of the 1,3-diketone moiety. Chembiochem: a European journal of chemical biology. 2002;3(4):364-70
72. Lian YT, Yang XF, Wang ZH, Yang Y, Yang Y, Shu YW, et al. Curcumin serves as a human kv1.3 blocker to inhibit effector memory T lymphocyte activities. Phytotherapy research: PTR. 2013;27(9):1321-7
73. Huang G, Yang Y, Xu Z, Zhou P, Gong W, Li Y, et al. Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-kappaB. European journal of pharmacology. 2011;650(1):451-7
74. Sun J, Zhao Y, Hu J. Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. PloS one. 2013;8(6):e67078
75. Mito S, Watanabe K, Harima M, Thandavarayan RA, Veeraveedu PT, Sukumaran V, et al. Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis. Biological & pharmaceutical bulletin. 2011;34(7):974-9
76. Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. Journal of immunology. 2002;168(12):6506-13
77. Chearwae W, Bright JJ. 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. Journal of clinical immunology. 2008;28(5):558-70
78. Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer research. 2002;22(6C):4179-81
79. De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, et al. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrobial agents and chemotherapy. 2009;53(4):1592-7
80. Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochemical and biophysical research communications. 2004;316(4):1065-72
81. Sintara K, Thong-Ngam D, Patumraj S, Klaikeaw N, Chatsuwan T. Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats. World journal of gastroenterology: WJG. 2010;16(32):4039-46
82. Zaidi SF, Yamamoto T, Refaat A, Ahmed K, Sakurai H, Saiki I, et al. Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells. Helicobacter. 2009;14(6):588-95
83. Kundu P, De R, Pal I, Mukhopadhyay AK, Saha DR, Swarnakar S. Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PloS one. 2011;6(1):e16306
84. Di Mario F, Cavallaro LG, Nouvenne A, Stefani N, Cavestro GM, Iori V, et al. A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure? Helicobacter. 2007;12(3):238-43
85. Kaur S, Modi NH, Panda D, Roy N. Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ--a structural insight to unveil antibacterial activity of curcumin. European journal of medicinal chemistry. 2010;45(9):4209-14
86. Bellio P, Brisdelli F, Perilli M, Sabatini A, Bottoni C, Segatore B, et al. Curcumin inhibits the SOS response induced by levofloxacin in Escherichia coli. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2013
87. Katsuyama Y, Hirose Y, Funa N, Ohnishi Y, Horinouchi S. Precursor-directed biosynthesis of curcumin analogs in Escherichia coli. Bioscience, biotechnology, and biochemistry. 2010;74(3):641-5
88. Mun SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, et al. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2013;20(8-9):714-8
89. Ribeiro AP, Pavarina AC, Dovigo LN, Brunetti IL, Bagnato VS, Vergani CE, et al. Phototoxic effect of curcumin on methicillin-resistant Staphylococcus aureus and L929 fibroblasts. Lasers in medical science. 2013;28(2):391-8
90. Xu F, Diao R, Liu J, Kang Y, Wang X, Shi L. Curcumin attenuates staphylococcus aureus-induced acute lung injury. The clinical respiratory journal. 2014
91. Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C. Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells. Biochemical and biophysical research communications. 2005;333(1):21-7
92. Divya CS, Pillai MR. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Molecular carcinogenesis. 2006;45(5):320-32
93. Maher DM, Bell MC, O'Donnell EA, Gupta BK, Jaggi M, Chauhan SC. Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Molecular carcinogenesis. 2011;50(1):47-57
94. Basu P, Dutta S, Begum R, Mittal S, Dutta PD, Bharti AC, et al. Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: a phase II randomized controlled study. Asian Pacific journal of cancer prevention: APJCP. 2013;14(10):5753-9
95. Sui Z, Salto R, Li J, Craik C, Ortiz de Montellano PR. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes. Bioorganic & medicinal chemistry. 1993;1(6):415-22
96. Mazumder A, Neamati N, Sunder S, Schulz J, Pertz H, Eich E, et al. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. Journal of medicinal chemistry. 1997;40(19):3057-63
97. Vajragupta O, Boonchoong P, Morris GM, Olson AJ. Active site binding modes of curcumin in HIV-1 protease and integrase. Bioorganic & medicinal chemistry letters. 2005;15(14):3364-8
98. Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries. Journal of the American College of Surgeons. 2005;200(6):820-30
99. Riva DA, Fernandez-Larrosa PN, Dolcini GL, Martinez-Peralta LA, Coulombie FC, Mersich SE. Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Archives of virology. 2008;153(3):561-5
100. Conteas CN, Panossian AM, Tran TT, Singh HM. Treatment of HIV-associated diarrhea with curcumin. Digestive diseases and sciences. 2009;54(10):2188-91
101. Gandapu U, Chaitanya RK, Kishore G, Reddy RC, Kondapi AK. Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro. PloS one. 2011;6(8):e23388
102. Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, et al. Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha. FEBS letters. 2010;584(11):2485-90
103. Kim K, Kim KH, Kim HY, Cho HK, Sakamoto N, Cheong J. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS letters. 2010;584(4):707-12
104. Tu CT, Han B, Liu HC, Zhang SC. Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression. Molecular and cellular biochemistry. 2011;358(1-2):53-60
105. Tu CT, Yao QY, Xu BL, Zhang SC. Curcumin protects against concanavalin A-induced hepatitis in mice through inhibiting the cytoplasmic translocation and expression of high mobility group box 1. Inflammation. 2013;36(1):206-15
106. Wang C, Nie H, Li K, Zhang YX, Yang F, Li CB, et al. Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice. European journal of pharmacology. 2012;697(1-3):152-7
107. Somanawat K, Thong-Ngam D, Klaikeaw N. Curcumin attenuated paracetamol overdose induced hepatitis. World journal of gastroenterology: WJG. 2013;19(12):1962-7
108. Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, et al. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut. 2013
109. Gomes Dde C, Alegrio LV, de Lima ME, Leon LL, Araujo CA. Synthetic derivatives of curcumin and their activity against Leishmania amazonensis. Arzneimittel-Forschung. 2002;52(2):120-4
110. Das R, Roy A, Ganguly A, Datta N, Majumder HK. WITHDRAWN:Curcumin, a dietary polyphenol, emerges as a novel inhibitor of DNA topoisomerase I of kinetoplastid parasite Leishmania donovani. The Biochemical journal. 2008
111. Chan MM, Adapala NS, Fong D. Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania. Parasitology research. 2005;96(1):49-56
112. Das R, Roy A, Dutta N, Majumder HK. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis: an international journal on programmed cell death. 2008;13(7):867-82
113. Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G. Curcumin-artemisinin combination therapy for malaria. Antimicrobial agents and chemotherapy. 2006;50(5):1859-60
114. Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN. Curcumin for malaria therapy. Biochemical and biophysical research communications. 2005;326(2):472-4
115. Cui L, Miao J, Cui L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrobial agents and chemotherapy. 2007;51(2):488-94
116. Vathsala PG, Dende C, Nagaraj VA, Bhattacharya D, Das G, Rangarajan PN, et al. Curcumin-arteether combination therapy of Plasmodium berghei-infected mice prevents recrudescence through immunomodulation. PloS one. 2012;7(1):e29442
117. Memvanga PB, Coco R, Preat V. An oral malaria therapy: curcumin-loaded lipid-based drug delivery systems combined with beta-arteether. Journal of controlled release: official journal of the Controlled Release Society. 2013;172(3):904-13
118. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics. 2007;4(6):807-18
119. Kumar V, Lewis SA, Mutalik S, Shenoy DB, Venkatesh, Udupa N. Biodegradable microspheres of curcumin for treatment of inflammation. Indian journal of physiology and pharmacology. 2002;46(2):209-17
120. Singh AK, Jiang Y, Gupta S, Younus M, Ramzan M. Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. Journal of medicinal food. 2013;16(10):899-911
121. Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK. Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response. Frontiers in oncology. 2013; 3:137

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