Jorjani Biomedicine Journal

en The Effect of four Weeks of Continuous Aerobic Training and Starvation on the Expression of Gene Pink1 and Bnibp3 in liver Tissue, liver Enzymes and lipid profile in Wistar Fatty Model Rats بهداشت Health تحقیقی Original article <div style="text-align: justify;">Background and Objective: Regular exercise along with calorie intake promotes mitochondrial function by promoting healthy mitochondrial regeneration. The aim of the present study was to investigate the effect of four weeksof continuous aerobic training and starvation on the gene expression of pink1 and bnibp3 (liver mitophagy) in Wistar fat rats. Materials and Methods: The present study used an experimental design. Thirty 18-week-old fatty, maleWistar rats with an average body weight of 348±25.53 purchased from the Pasteur Institute of Iran were selected as the research sample. After one week of familiarity with the laboratory environment, these fatty animals were randomly divided into 6 groups of 5, control (n=5) and experimental (n=25), including control, starvation, starvation and 3 days of exercise, starvation and 5 days of exercise, 3 days of exercise, 5 days of exercise groups. Results: According to the statistical results of one-way analysis of variance, there was a significant decrease in triglyceride, cholesterol, liver enzymes ALT, AST in all groups compared to the control group. Furthermore, there was a significant increase in pink1 and bnibp3 gene expression in starvation group and starvation groups of 3 and 5 days of training compared to the control group. Conclusion: Four weeksof continuous aerobic training and starvation combined and alone were able to significantly reduce the status of blood lipids and liver enzymes in fatty model rats. Also, the starvation group and starvation groups along with exercise increased the activity of removing damaged mitochondria by increasing the activity of pink1 and bnibp3 genes compared to the control group.  </div> Non-alcoholic Fatty Liver Disease,Starvation,Exercise,Lipid Droplets,Mitophagy,PTEN-induced putative kinase, 15 25 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-890-1&slc_lang=en&sid=1 hamzeh bayani Hamzeh_bayani@yahoo.com 10031947532846008327 0000000279562780 No Department of Physical Education & Sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran Habib Asgharpour Habibasgharpour@gmail.com 10031947532846008328 000000024116981x Yes Department of Physical Education & Sports Sciences, Aliabad katoul branch, Islamic Azad University, Aliabad Katoul, Iran asra askari Askari.asra@gmail.com 10031947532846008329 0000000249489658 No Department of Physical Education, Gorgan Branch, Islamic Azad University, Gorgan, Iran Reza Rezaeeshirazi Dr.rezaee@aliabadiau.ac.ir 10031947532846008330 0000000166187187 No Department of Physical Education & sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran