en علوم پایه پزشکی Basic Medical Sciences تحقیقی Original article <div style="text-align: justify;"><span style="font-size:14px;"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background and objectives:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> The fatty liver is a reversible form of fat accumulation in the liver cells. The burden of this disease is increasing worldwide.&nbsp; In general, due to the lack of proper treatment and the multiple side effects of existing chemical medicines, researchers have focused on the use of herbal medicines. The aim of this study was to evaluate the therapeutic effects of aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) on fatty liver in rats fed with high fat diet as respects these plants have been frequently applied in traditional medicine for treatment of the liver-related diseases.<b><i></i></b></span></span></span></span><br> <span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Material and Methods:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into 5 groups and received 125, 250, 500 and 1000 mL/kg of mixture of aqueous extracts of burdock and chicory.<b><i></i></b></span></span></span></span><br> <span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results: </span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results showed that this aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. It was found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect.<b><i></i></b></span></span></span></span><br> <span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><i><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with high-fat diet. This study provides evidence that burdock-chicory extract could be considered as a potential dietary supplement strategy for prevention and treatment of fatty liver. Based on these results, the extract was formulated, and entered the pharmaceutical market.</span></span></span></span></span><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:9.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></div> Fatty Liver,Aspartate Aminotransferases,Alanine Transaminase,Arctium lappa L. (burdock),Cichorium intybus L. (chicory), 53 61 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-759-1&slc_lang=en&sid=1 Mohammad Jafari Shiran dmjaafari@gmail.com 10031947532846008004 10031947532846008004 No Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran Saeed Naseri naseri.herbalpharma@gmail.com 10031947532846008005 10031947532846008005 No Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Tahereh Sadeghian-Rizi t.sadeghian@ashrafi.ac.ir 10031947532846008006 10031947532846008006 No Department of Biotechnology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran Saeed Khani saeid.khani@gmail.com 10031947532846008007 10031947532846008007 No Islamic Medicine Pioneers Company, Ardabil, Iran Mohammad Shoormij denis.jimmy87@gmail.com 10031947532846008008 10031947532846008008 No Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Seyedeh Simin Dakhilpour s.dakhilpour@uma.ac.ir 10031947532846008009 10031947532846008009 Yes Researcher of Traditional Medicine and Medicinal Plants, Iranian Academy Center for Education, Culture and Research (ACECR), Medicinal Herbal Center, Ardabil Branch, Ardabil, Iran