Volume 8, Issue 4 (12-2020)
Jorjani Biomed J 2020, 8(4): 11-16 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Azizi R, Mohammadi A, Khajehlandi A. The Effect of Aqueous Extract of Barberry and Selected Training on some Blood Factors in Men with Type2 Diabetes
(A Quasi-Experimental Study). Jorjani Biomed J 2020; 8 (4) :11-16
URL: http://goums.ac.ir/jorjanijournal/article-1-764-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-764-en.html
1- Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran
2- Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran ,amin.mohammadi8@gmail.com
2- Department of Physical Education and Sport Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran ,
Abstract: (5069 Views)
Background and Objective: Although the efficacy of selected training and antioxidant herbs in the treatment of diabetes mellitus has been determined, the interactive effect of selected training and aqueous extract of barberry on insulin resistance and risk factors of type2 diabetes mellitus is not well understood. The aim of the present study was to investigate the effect of aqueous extract of barberry and selected training on some blood factors in men with type2 diabetes.
Material and Methods: In this study, 48 middle-aged men an age range of 40-50 years with type2 diabetes participated in the study. The participants were randomly divided into four groups of 12 subjects, including(1)control, (2)aqueous extract of barberry consumption, (3)aerobic training, and (4)aerobic training+ barberry consumption, based on insulin resistance index. The participants in the aqueous extract of barberry consumption group received200 ml of barberry juice daily for8 weeks and the training and training+ barberry consumption groups performed the training protocol designed in the study for 8 weeks, while the control group did not receive any intervention.
Results: After 8 weeks of exercise training and consumption of aqueous extract of barberry, insulin resistance index, fasting insulin level, fasting blood glucose level, triglyceride level, low density lipoprotein (LDL)and total cholesterol were significantly decreased compared to the control group and high density lipoprotein (HDL)had a significant increase; on the other hand, regarding the intergroup changes, only the levels of LDL and CHO were significant compared to the aqueous extract of barberry consumption and aerobic training.
Conclusion: In general, aqueous extract of barberry consumption and regular exercise training seems to be effective in improving insulin resistance index and blood lipids levels in type2 diabetic patients.
Material and Methods: In this study, 48 middle-aged men an age range of 40-50 years with type2 diabetes participated in the study. The participants were randomly divided into four groups of 12 subjects, including(1)control, (2)aqueous extract of barberry consumption, (3)aerobic training, and (4)aerobic training+ barberry consumption, based on insulin resistance index. The participants in the aqueous extract of barberry consumption group received200 ml of barberry juice daily for8 weeks and the training and training+ barberry consumption groups performed the training protocol designed in the study for 8 weeks, while the control group did not receive any intervention.
Results: After 8 weeks of exercise training and consumption of aqueous extract of barberry, insulin resistance index, fasting insulin level, fasting blood glucose level, triglyceride level, low density lipoprotein (LDL)and total cholesterol were significantly decreased compared to the control group and high density lipoprotein (HDL)had a significant increase; on the other hand, regarding the intergroup changes, only the levels of LDL and CHO were significant compared to the aqueous extract of barberry consumption and aerobic training.
Conclusion: In general, aqueous extract of barberry consumption and regular exercise training seems to be effective in improving insulin resistance index and blood lipids levels in type2 diabetic patients.
Type of Article: Original article |
Subject:
Health
Received: 2020/09/23 | Accepted: 2020/10/13 | Published: 2020/11/30
Received: 2020/09/23 | Accepted: 2020/10/13 | Published: 2020/11/30
References
1. World Health Organization. Global report on diabetes, Geneva, 2016. [view at publisher] [Google Scholar]
2. Azizi, Fereydoon. Epidemiology of diabetes in Iran.New Horizons Seminar on Diabetes Education and Treatment, 2001; Tehran, Iran, Foundation for Special Diseases Affairs.Persian [Google Scholar]
3. Suji G, Sivakami S. Approaches to the treatment of diabetes mellitus: an overview. Cell MolBiol 2003; 49:635-639. PMID: 12899455 [view at publisher] [Google Scholar]
4. ZovkoKoncic M, Kremer D, Karlovic K, Kosalec I. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and BerberiscroaticaHorvat. Food ChemToxicol 2010; 48: 2176-2180. [view at publisher] [DOI] [Google Scholar]
5. Aliakbarlu J, Ghiasi S, Bazargani-Gilani B. Effect of extraction conditions on antioxidant activity of barberry (Berberis vulgaris L.) fruit extracts. Vet Res Forum. 2018;9(4):361-365. [view at publisher] [Google Scholar]
6. Lazavi F, Mirmiran P, Sohrab, G., Eshkevari, N. and Hedayati, M., 2016. Effect of barberry juice consumption on blood pressure in patients with type 2 diabetes.Research in Medicine, 39(4), pp.183-188. Persian URL: http://pejouhesh.sbmu.ac.ir/article-1-1488-en.html [view at publisher] [Google Scholar]
7. Fatehi M, Saleh TM, Fatehi-Hassanabad Z. A pharmacological study on Berberis Vulgaris fruit extract.J Ethnopharm 2005; 102: 46-52. [view at publisher] [DOI] [Google Scholar]
8. Mahdavi N, Joukar S, Najafipour H, Asadi-ShekaariM.The promising effect of barberry (Zereshk) extract against experimental pulmonary microvascular remodeling and hypertension: A comparison with Sildenafil. Journal of Pharmaceutical Biology 2015.http://dx. [view at publisher] [DOI] [Google Scholar]
9. Lazavi F, Mirmiran P, Sohrab G, Nikpayam O, Angoorani P, Hedayati M. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: A randomized clinical trial. Complement TherClinPract 2018; 31: 170-174. [view at publisher] [DOI] [Google Scholar]
10. Ebrahimi M M; ArefHussini S R ;Askarzadeh A A; Golzarand M." Effect of Berberis vulgaris processed apple cider vinegar on blood pressure and inflammatory factors in patients with type 2 diabetes". Iranian Journal of Diabetes and Lipid, 2008, No. 3: 289-296.Persian [Google Scholar]
11. Safari Z, Farrokhzad A, Ghavami A, et al. The effect of barberry (Berberis vulgaris L.) on glycemic indices: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2020;51:102414. [view at publisher] [DOI] [Google Scholar]
12. Kalmarzi RN, Naleini SN, Ashtary-Larky D, Peluso I, Jouybari L, et al. Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds. Oxidative Medicine and Cellular Longevity, 2019. [view at publisher] [DOI] [Google Scholar]
13. Amini MR, Sheikhhossein F, Naghshi S, et al. Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2020; 49:102337. [view at publisher] [DOI] [Google Scholar]
14. Nematollahzadehmahani M, Ghasemian poor J. Effects of lifestyle activity modification on insulin resistance and pancreatic β-cells function in obese men with insulin resistance. J Physic Act Horm 2018; 2: 29-44. http://jpah.iaushiraz.ac.ir/article_544700.html [view at publisher] [Google Scholar]
15. Derouich M, Boutayeb A. The effect of physical exercise on the dynamics of glucose and insulin. J Biochem 2002; 35: 911-917. [view at publisher] [DOI] [Google Scholar]
16. Elmahgoub SM, Lambers S, Stegen S, Van Laethem C, Cambier D, Calders P. The influence of combined exercise training on indices of obesity, physical fitness and lipid profile in overweight and obese adolescents with mental retardation.Eur J Pediatr 2009; 168: 1327-1333. [view at publisher] [DOI] [Google Scholar]
17. Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise Training for Type 2 Diabetes Mellitus: Impact on Cardiovascular Risk: A Scientific Statement From the American Heart Association. Circulation.2009; 119:3244-3262. [view at publisher] [DOI] [Google Scholar]
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419. [view at publisher] [DOI] [Google Scholar]
19. Bijeh N, Mabhotmoghadam T, Shahin M." The Effect of Short-Term Supplementation of Cranberry Extract on Glycemic Index in Patients with Type 2 Diabetes Following an Aerobic Exercise Session".2015;Vol 3 .Journal of medical science Fasa;pp503-518. Persian [Google Scholar]
20. Ashraf H؛ Hidary H؛ Nejati V؛ IlkhanipoorM."Preventive effect of aqueous extract of barberry root on blood glucose levels and serum lipids in streptozotocin-induced diabetic rats". Journal of Fasa University of Medical Sciences, 2012, No. 3: 148-154.PMID: 25561940 [Google Scholar]
21. Zhou L, Yang Y, Wang X, Liu S, Shang W, Yuan G, et al. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 2007; 56: 405-412. [view at publisher] [DOI] [Google Scholar]
22. Gao CR, Zhang JQ, Huang QL. Experimental study on berberin raised insulin sensitivity in insulin resistance rat models. ZhongguoZhong Xi Yi Jie He ZaZhi 1997; 17: 162-164.PMID: 9863084 [view at publisher] [Google Scholar]
23. Ebrahimi-Mamaghani, M., Arefhosseini, S.R., Golzarand, M., Aliasgarzadeh, A. and Vahed-Jabbary, M., 2009. Long-term effects of processed Berberis vulgaris on some metabolic syndrome components.Iranian Journal of Endocrinology and Metabolism, 11(1).URL: http://ijem.sbmu.ac.ir/article-1-709-en.html [Google Scholar]
24. Bweir S, Al-Jarrah M, Almalty AM, Maayah M, Smirnova IV, Novikova L. Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes. DiabetolMetabSyndr. 2009 Dec; 10(1): 27. [view at publisher] [DOI] [Google Scholar]
25. Cho K, Kim YB. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med. 2010 Jun; 25(2): 119-29. [view at publisher] [DOI] [Google Scholar]
26. Wang Y, Simar D, FiataroneSingh M. Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review. Diabetes Metab Res Rev. 2009 Jan; 25(1): 13-40. doi: 10.1002/dmrr.928. [view at publisher] [DOI] [Google Scholar]
27. Albright A, Franz M, Hornsby G, Krika A, Marrero D, Ullrich I et al. Exercise and type 2 diabetes. Med sci sports Exrcise 2000; 32 (7): 1345- 1360. [DOI] [Google Scholar]
28. Yavari A, Nagaphipour F, Asgarzadeh AA, Niafar M, Mobseri M, Nikokhoslat S. The effect of aerobic, resistance and combined on control of blood glucose and cardiovascular risk factors in type 2 diabetes patients. J Tabriz Med Sci 2011; 33(4): 82-91. [Google Scholar]
29. Kaliora AC, Dedoussis GV. Natural antioxidant compounds in risk factors for CVD. Pharmacol Res. 2007; 56: 99-109. [view at publisher] [DOI] [Google Scholar]
30. Harris CS, Beaulieu LP, Fraser MH, McIntyre KL, Owen PL, Martineau LC, et al. Inhibition of advanced glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity. Planta Med 2011; 77: 196-204. [DOI] [Google Scholar]
31. Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, et al. Berberine is a novel cholesterol lowering drug working through a unique mechanism distinct from statins. Nature Med 2004; 10: 1344-1351. [view at publisher] [DOI] [Google Scholar]
32. Arayne MS, Sultana N, and Bahadur SS. The berberis story: Berberis vulgaris in therapeutics. Pak J Pharm Sci 2007; 20: 83-92.PMID: 17337435. [view at publisher] [Google Scholar]
33. Sobolova L, Skottova N, Vecera R, Urbanek K. Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacol Res 2006; 53: 104-12. [view at publisher] [DOI] [Google Scholar]
34. Goue'dard C, Barouki R, Morel Y. Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Moll Cell Biol 2004; 24: 5209-22. [view at publisher] [DOI] [Google Scholar]
35. Skottova N, Vecera R, Urbanek K, Vana P, Walterova D, Cvak L. Effects of polyphenolic fraction of silymarin on lipoprotein profile in rats fed cholesterol-rich diets. Pharmacol Res 2003; 47: 17-26. [view at publisher] [DOI] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
